In Chapter 1 the story of immunosuppression was left at the stage when it had become clear that whole body irradiation would not become a useful clinical tool. In 1958 Dameshek and Schwartz in the New England Medical Center were attempting to treat aplastic anaemia and leukaemia with bone marrow transplantation. They too tried irradiation of the recipient and found a high mortality. In search of a better method they reasoned that an anticancer drug such as 6-mercaptopurine (6 MP) might be used and reported that rabbits treated with this drug showed little response to injection of foreign protein. Their report led Calne in London, and Zukoski in Richmond, Virginia, to use 6 MP for kidney transplants in dogs, with some success, but this too proved to be toxic and some of the animals died.
KeywordsGraft Survival Triple Therapy Graft Function White Cell Count Rejection Episode
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