Abstract
We studied the numbers of T cell receptor (TCR) gamma/delta (τ/δ) bearing lymphocytes in 45 jejuna] specimens from 19 patients with coeliac disease (CD), 6 patients with dermatitis herpetiformis (DH), and 13 controls with normal jejunum and one patient with villous atrophy and severe food allergy. Monoclonal antibodies and a three-layer peroxidase staining method were used. In the lamina propria and epithelium of a normal jejunum and in the specimen of the patient with food allergy only low numbers of τ/δ+ cells were seen. In the lamina propria of coeliac patients, the mean number of τ/δ + cells was significantly higher than in the controls before treatment, during gluten free diet and after the gluten challenge. Patients with DH were on normal diet; they showed a similar increase of τ/δ+ cells as CD patients. In the jejunal surface and crypt epithelium of CD patients, the number of τ/δ+ cells was elevated before and during gluten elimination and after the challenge test. In the epithelium, the absolute number of these cells remained constant during gluten elimination and provocation. In the specimens of DH patients a similar increase was seen; in both groups the mean number of τ/δ+ was about 30% of that of CD3+ cells. We infer that the elevated population of τ/δ+ T cells in the epithelium of CD and DH patients may play an important role in the pathogenesis of jejunal damage.
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© 1991 Springer Science+Business Media Dordrecht
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Savilahti, E., Arato, A., Reunala, T., Verkasalo, M. (1991). Intestinal Gamma/Delta Receptor Bearing T Lymphocytes are Increased in Coeliac Disease and Dermatitis Herpetiformis. In: Mearin, M.L., Mulder, C.J.J. (eds) Coeliac Disease. Developments in Gastroenterology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7943-8_12
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DOI: https://doi.org/10.1007/978-94-015-7943-8_12
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