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Intermolecular Forces pp 445–464Cite as

A Model for Drug-Receptor Interactions: The Opiate Receptor. A Preliminary Report

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Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 14))

Abstract

Theoretical conformational analysis studies using classical, empirical potential energy functions have been carried out on a proposed model opiate binding site, cerebroside sulfate. The methods used in these calculations are discussed. Current efforts involve the interaction of opiates with the low energy conformers of cerebroside sulfate. Preliminary results indicate that cerebroside sulfate is able to adopt a conformation which is complementary to the opiate pharmacophorc pattern.

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References

  1. H.H. Loh, T.M. Cho, Y.-C. Wu, E.L. Way, Life Sci, 14, pp. 2231 (1974)

    Article  CAS  Google Scholar 

  2. T.M. Cho, H.H. Loh, E.L. Way, Proc. West Pharmacol. Soc., 18, pp. 176 (1975).

    CAS  Google Scholar 

  3. J.S. Cho, T.M. Cho, H.H. Loh, E.L. Way, Proc. West Pharmacol. Soc., 28, pp. 298 (1975).

    Google Scholar 

  4. H.H. Loh, T.M. Cho, Y.-C. Wu, R.A. Harris, E.L. Way, Life Sci., 16, pp. 1811 (1975).

    Article  CAS  Google Scholar 

  5. H.H. Loh, T.M. Cho, Y.-C. Wu, Fed Proc, 34, pp. 815 (1975).

    Google Scholar 

  6. H.H. Loh, T.M. Cho, in “Tissue Responses to Addictive Drugs”, D.H. Ford, D.H. Clovet, eds, Spectrum Publications, New York, pp. 355 (1976).

    Google Scholar 

  7. T.M. Cho, J.S. Cho, H.H. Loh, Life Sci., 18, pp. 231 (1976).

    Article  CAS  Google Scholar 

  8. T.M. Cho, J.S. Cho, H.H. Loh, Life Sci., 19, pp. 117 (1976).

    Article  CAS  Google Scholar 

  9. P.Y. Law, R.A. Harris, H.H. Loh, E.L. Way, J. Pharm. Exptl. Ther., 207(2), pp. 458 (1978).

    CAS  Google Scholar 

  10. H.H. Loh, P.Y. Law, T. Ostwald, T.M. Cho, E.L. Way, Fed. Proc, 37(2), pp. 147 (1978).

    CAS  Google Scholar 

  11. D.A. Johnson, R. Cooke, H.H. Loh, Mol. Pharmacol., 16, pp. 154 (1979

    CAS  Google Scholar 

  12. T.M. Cho, J.S. Cho, H.H. Loh, Mol. Pharmacol., 16, pp. 393 (1979).

    CAS  Google Scholar 

  13. P.Y. Law, G. Fischer, H.H. Loh, A. Herz, Biochem. Pharmacol., 28, pp. 2557 (1979).

    Article  CAS  Google Scholar 

  14. F.B. Craves, B. Zalc, L. Leybin, N. Bavmann, H.H. Loh, Science, 207, pp. 75 (1980).

    CAS  Google Scholar 

  15. G. Dawson, S.M. Kernes, R.J. Miller, B. Wainer, J. Biol. Chem., 253, pp. 7999 (1978).

    CAS  Google Scholar 

  16. E.J. Simon, J.M. Hiller, Fed. Proc, 37, pp. 141 (1978).

    CAS  Google Scholar 

  17. S.H. Snyder, S. Matthysse, Neurosci. Res. Progr. Bull., 13, pp. 1 (1975).

    CAS  Google Scholar 

  18. R.S. Zukin, R.M. Kream, Proc. Nat. Acad. Sci. USA, 76, pp. 1593 (1979).

    Article  CAS  Google Scholar 

  19. L.G. Abood, W. Hoss, Eur. J. Pharmacol., 32 pp. 66 (1975).

    Article  CAS  Google Scholar 

  20. L.G. Abood, F. Takeda, Eur. J. Pharmacol., 39, pp. 71 (1976).

    Article  CAS  Google Scholar 

  21. S.G. Dennis, Progr. Neuro-Psychopharmacol., 4, pp. 111 (1980).

    Article  CAS  Google Scholar 

  22. L.I. Lowney, K. Schulz, P.J. Lowery, A. Goldstein, Science, 183, pp. 749 (1974).

    CAS  Google Scholar 

  23. A.H. Beckett, A.F. Casy, J. Pharm. Pharmacol., 6, pp. 986 (1954).

    Article  CAS  Google Scholar 

  24. P.S. Portoghese, J. Med. Chem., 8, pp. 609 (1965).

    Article  CAS  Google Scholar 

  25. D.S. Berkowitz, G.H. Loew, in “Opiates Endogenous Opioid Peptides”, H.W. Kosterlitz, (ed), North Holland Publishing Co., Amsterdam, pp. 387 (1976).

    Google Scholar 

  26. P.J. Andrée, Biochem., 17, pp. 772 (1978).

    Article  Google Scholar 

  27. D.A. Kooistra and J.H. Richards, Biochem., 17, pp. 2960 (1978).

    Google Scholar 

  28. M.H. O’Leary and J.R. Payne, J. Biol. Chem., (1978), 251, pp. 2248 (1976).

    Google Scholar 

  29. A.S. Mildvan, Acc. Chem. Res., 10, pp. 246 (1977).

    Article  CAS  Google Scholar 

  30. R.L. Kastrup, M.A. Young and T.R. Krugh, Biochem., 17, pp. 4855 (1978).

    Article  CAS  Google Scholar 

  31. H.J.R. Weintraub, Ph.D. dissertation, Case Western Researve University, Cleveland, Ohio (1975).

    Google Scholar 

  32. H.J.R. Weintraub, A.J. Hopfinger, Int. J. Quantum Chem., QBS2, pp. 203 (1975).

    CAS  Google Scholar 

  33. R. Potenzone, Jr., E. Cavicchi, H.J.R. Weintraub, A.J. Hopfinger, Computers and Chem, 1, pp. 187 (1977).

    Article  CAS  Google Scholar 

  34. R. Potenzone, Jr., E. Cavicchi, H.J.R. Weintraub, A.J. Hopfinger, Computers and Chem, 1, pp. 187 (1977).

    Article  CAS  Google Scholar 

  35. H.J.R. Weintraub and A.J. Hopfinger, in “Jerusalem Symposium on Quantum Chemistry and Biochemistry”, Vol. 7, E.D. Bergmann and B. Pullman, Eds. (Reidel, Boston, MA, 1974), pp. 131.

    Google Scholar 

  36. H.J.R. Weintraub et al., Int. J. Quant. Chem., Quant. Biol. Symp., 3, pp. 99 (1976).

    CAS  Google Scholar 

  37. H.J.R. Weintraub, Int. J. Quant. Chem., Quant. Biol. Symp., 4, pp. 111 (1977).

    CAS  Google Scholar 

  38. H.J.R. Weintraub and D.E. Nichols, Int. J. Quant. Chem., Quant. Biol. Symp., 5, pp. 321 (1978).

    CAS  Google Scholar 

  39. R. Potenzone, Jr., M.S. Thesis, Case Western Reserve University, Cleveland, OH, 1975.

    Google Scholar 

  40. R. Potenzone, Jr. and A.J. Hopfinger, Carbohydrate Res., 40, pp. 444 (1975).

    Article  Google Scholar 

  41. A.J. Hopfinger, Conformational Properties of Macromolecules (Academic, New York, 1973).

    Google Scholar 

  42. T. Ooi, R.A. Scott, G. Vanderkooi, and H.A. Scheraga, J. Chem. Phys., 46, pp. 4410 (1967).

    Article  CAS  Google Scholar 

  43. H.A. Scheraga, Adv. Phys. Org. Chem., 6, pp. 103 (1968).

    CAS  Google Scholar 

  44. D.R. Hershbach, “Bibliography for Hindered Internal Rotation and Microwave Spectroscopy”, Lawrence Radiation Lab., Univ. of California, Berkeley, California (1962).

    Book  Google Scholar 

  45. J.D. Roberts, “Nuclear Magnetic Resonance”, McGraw Hill, New York (1959).

    Google Scholar 

  46. F.A. Bovey, “High Resolution NMR of Macromolecules”, Academic Press, New York (1972).

    Google Scholar 

  47. K.D. Gibson and H.A. Scheraga, Proc. Nat. Acad. Sci. USA, 58, pp. 420 (1967).

    Article  CAS  Google Scholar 

  48. A.J. Hopfinger, Macromolecules 4, pp. 731 (1971).

    Article  CAS  Google Scholar 

  49. A.J. Hopfinger and R.D. Battershell, J. Med. Chem. 19, pp. 569 (1976).

    Article  CAS  Google Scholar 

  50. M. Perricaudet, A. Pullman, Int. J. Peptide Protein Res., 5, pp. 99 (1973).

    Article  CAS  Google Scholar 

  51. H.J.R. Weintraub, in “Computer-Assisted Drug Design”, E. Olson, R.E. Christoffersen, eds, ACS Symposium Series, 112, Chapter 17, pp. 353 (1979).

    Chapter  Google Scholar 

  52. F. Longchambon, J. Ohannesian, D. Avenel, A. Neuman, Acta Cryst B, 31 (1975).

    Google Scholar 

  53. E. Shefter, S. Singh, T. Brennan, P. Sackman, Crystal Struc. Comm., 3, pp. 209 (1974).

    CAS  Google Scholar 

  54. S.R. Heller, G.W.A. Milne, R.J. Feldman, Science, 195(4275), pp. 253 (1977).

    CAS  Google Scholar 

  55. L.E. Sutton, “Tables of Interatomic Distances and Configurations in Molecules and Ions,” Chemical Society Spec. Publ. 11, 1958; Suppl. 18 (1965).

    Google Scholar 

  56. MMI/MMPI/MMII: N.L. Allinger, et al, as amended by H. Hönig, QCPE, 13, pp. 404 (1981).

    Google Scholar 

  57. MNDO: W. Thiel, QCPE, 11, pp. 353 (1978).

    Google Scholar 

  58. CNINDO/74: P.A. Dobosh, N.S. Ostlund, QCPE, 11, pp. 281 (1975).

    Google Scholar 

  59. P.J. Flory, “Statistical Mechanics of Chain Molecules”, Interscience, New York (1969).

    Google Scholar 

  60. T. Shimanouchi, Disc. Faraday Soc., 49, pp. 60 (1970).

    Article  Google Scholar 

  61. S. Mizushima, T. Shimanouchi, J. Am. Chem. Soc., 86, pp. 3521 (1964).

    Article  CAS  Google Scholar 

  62. C.W. Bunn, Trans. Faraday Soc., 35, pp. 482 (1939).

    Article  CAS  Google Scholar 

  63. G. Natta, P. Corradini, P. Ganis, Makromol. Chem., 39, pp. 238 (1960).

    Article  CAS  Google Scholar 

  64. G. Smith, P. Gund, J. Chem. Inf. Comput. Sci., 4, pp. 207 (1978).

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN, 47907, USA

    H. J. R. Weintraub

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  1. H. J. R. Weintraub
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Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université Pierre et Marie Curie (Paris VI), Paris, France

    Bernard Pullman

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Weintraub, H.J.R. (1981). A Model for Drug-Receptor Interactions: The Opiate Receptor. A Preliminary Report. In: Pullman, B. (eds) Intermolecular Forces. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7658-1_28

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  • DOI: https://doi.org/10.1007/978-94-015-7658-1_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-8368-5

  • Online ISBN: 978-94-015-7658-1

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