Summary
Protein exportation is a process whereby at least a portion of a polypeptide chain is transfered across a lipid bilayer. Most exported proteins are made as precursors with a N-terminal extension -the signal peptide- which is removed upon exportation.
We review briefly current ideas about the rôle of the signal peptide. We discuss in particular the case of bacterial signal peptides and define a parameter -the Hydrophobic Axis Length (H.A.L.)— which allow to account for the properties of the mutations presently known in bacterial signal peptides.
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Hugues, B., Maurice, H. (1981). On the Role of the Signal Peptide in the Initiation of Protein Exportation. In: Pullman, B. (eds) Intermolecular Forces. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7658-1_23
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DOI: https://doi.org/10.1007/978-94-015-7658-1_23
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