Prevention of postoperative adhesions

  • W. H. Utian


I had hoped to say ‘Eureka! I have got it!’ in referring to an effective and safe adjuvant for the prevention of postoperative adhesions. Regrettably and truthfully this is not the case. Indeed, I would have been wiser to have entitled this presentation ‘The Practical and Logistical Problems Encountered in Testing Adjuvants for Prevention of Postoperative Adhesions’. I will expand on this aspect shortly in relation to my own experience with the high molecular weight dextrans.


Adhesion Formation Postoperative Adhesion Pelvic Adhesion Adhesion Prevention American Fertility Society 
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  1. 1.
    Goldfarb, J. M., Utian, W. H. and Weiss, R. (1983). Microscopic versus macroscopic tubal anastomosis in rabbit fallopian tubes. Fertil. Steril. (In press)Google Scholar
  2. 2.
    Verhoeven, H. C., Berry, H., Frantzen, C. and Schlosser, H. (1983). Surgical treatment for distal tubal occlusion. A review of 167 cases. J. Reprod. Med., 28, 293PubMedGoogle Scholar
  3. 3.
    Swolin, K. (1977). Laparoscopy as an operative tool in female sterility. J. Reprod. Med., 19, 167PubMedGoogle Scholar
  4. 4.
    DiZerega, G. and Utian, W. H. (1982). Efficacy of 32% dextran-70 in the prevention of peritoneal adhesions, and the utility of the second-look laparoscopy in infertility surgery. Fertil. Steril., 37, 291Google Scholar
  5. 5.
    Daniell, J. F. and Pittaway, D. E. (1983). Short-interval second-look laparoscopy after infertility surgery. J. Reprod. Med., 28, 281PubMedGoogle Scholar
  6. 6.
    Bateman, B. G., Nunley, W. C. and Kitchin, J. D. (1982). Prevention of postoperative peritoneal adhesions with ibuprofen. Fertil. Steril., 38, 107PubMedGoogle Scholar
  7. 7.
    Weinstein, D. and Polishuk, W. Z. (1975). The role of wedge resection of the ovary as a cause for mechanical sterility. Surg. Gynecol. Obstet., 141, 417PubMedGoogle Scholar
  8. 8.
    DiZerega, G. S. (1980). The Cause and Prevention of Postsurgical Adhesions. (National Institutes of Health, Bethesda, MD: Pregnancy Research Branch )Google Scholar
  9. 9.
    Holtz, G. (1980). Prevention of postoperative adhesions. J. Reprod. Med., 24, 141PubMedGoogle Scholar
  10. 10.
    Levinson, C. J. and Swolin, K. (1980). Postoperative adhesions: etiology, prevention and therapy. Clin. Obstet. Gynecol., 23, 1213PubMedCrossRefGoogle Scholar
  11. 11.
    Eskeland, G. (1964). Regeneration of parietal peritoneum. Acta Path. Microbiol. Scand., 62, 459PubMedGoogle Scholar
  12. 12.
    Rafferty, A. T. (1967). Regeneration of parietal and visceral peritoneum: An enzyme histochemical study. J. Anat., 121, 589Google Scholar
  13. 13.
    Buckman, R. F., Buckman, P. D., Hufnagel, H. V., et al. (1976). A physiologic basis for the adhesion-free healing of deperitonealized surfaces. J. Surg. Res., 21, 67PubMedCrossRefGoogle Scholar
  14. 14.
    Choe, J. K., Dawood, Y. and Andrews, A. H. (1983). Conventional versus laser reanastomosis of rabbit ligated uterine horns. Obstet. Gynecol., 61, 689PubMedGoogle Scholar
  15. 15.
    Siegler, A. M., Kontopolous, V. and Wang, C. F. (1980). Prevention of postoperative adhesions in rabbits with ibuprofen, a non-steroidal anti-inflammatory agent. Fertil. Steril., 34, 46PubMedGoogle Scholar
  16. 16.
    Holtz, G. D. (1982). Failure of a non-steroidal anti-inflammatory agent (Ibuprofen) to inhibit peritoneal adhesion formation after lysis. Fertil. Steril., 37, 582PubMedGoogle Scholar
  17. 17.
    O’Brien, W. F., Drake, T. S. and Bibro, M. C. (1982). The use of ibuprofen and dexamethasone in the prevention of postoperative adhesion formation. Obstet. Gynecol., 60, 373PubMedGoogle Scholar
  18. 18.
    Seitz, H. M., Schenker, J. G. et al. (1973). Postoperative intraperitoneal adhesions: A double-blind assessment of their prevention in the monkey. Fertil. Steril., 24, 935PubMedGoogle Scholar
  19. 19.
    DiZerega, G. S. and Hodgen, G. D. (1980). Prevention of postsurgical tubal adhesions: Comparative study of commonly used agents. Am. J. Obstet. Gynecol., 136, 173PubMedGoogle Scholar
  20. 20.
    Granat, M., Schencker, J. G., et al. (1938). Effects of dexamethasone on proliferation of autologous fibroblasts and on the immune profile in women undergoing pelvic surgery for infertility. Fertil. Steril., 39, 180Google Scholar
  21. 21.
    Utian, W. H. (1980). Prevention of adhesions after tubal surgery by use of dextran70. S. Afr. Med. J., 58, 204PubMedGoogle Scholar
  22. 22.
    Neuwirth, R. S. and Khalaf, S. M. (1975). Effect of thirty-two percent dextran 70 on peritoneal adhesion formation. Am. J. Obstet. Gynecol., 121, 420PubMedGoogle Scholar
  23. 23.
    Utian, W. H., Goldfarb, J. M. and Starks, G. C. (1979). Role of dextran 70 in microtubal surgery. Fertil. Steril., 31, 79PubMedGoogle Scholar
  24. 24.
    The Adhesion Study Group (1983). Reduction of postoperative pelvic adhesions with intraperitoneal dextran-70: A prospective, randomized study. Fertil. Steril. (In press)Google Scholar
  25. 25.
    Bernstein, J., Mattox, J. H. et al. (1982). The potential for bacterial growth with dextran. J. Reprod. Med., 27, 77PubMedGoogle Scholar
  26. 26.
    Borten, M., Seibert, C. P. and Taymor, M. D. (1983). Recurrent anaphylactic reaction to intraperitoneal dextran 75 used for prevention of postsurgical adhesions. Obstet. Gynecol., 61, 755PubMedGoogle Scholar

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© MTP Press Limited 1984

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  • W. H. Utian

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