Skip to main content

Gonadotrophin-resistant ovaries: a desensitization syndrome?

  • Chapter
Clinical Pathology of the Endocrine Ovary

Abstract

Insensitivity to protein hormones can be due to a variety of mechanisms. In the human, ovarian resistance to PMSG has been known for a long time: it is related to the development of antibodies to this foreign protein.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aharonov, A., Abramsky, O., et al. (1975). Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis. Lancet, 2, 340–2

    Article  PubMed  CAS  Google Scholar 

  2. Jones, G. S. and de Moraes-Ruehsen, M. (1969). A new syndrome of amenorrhea in association with hypergonadotropism and apparently normal ovarian follicular apparatus. Am. J. Obstet. Gynecol., 104, 597–600

    PubMed  CAS  Google Scholar 

  3. Netter, A., Lambert, A., Lumbroso, P., Mantel, O. and Faure (1957). Aménorrhées ovario-plégiques (ménopauses neurogènes). Ann. Endocrinol., 18, 1014–20

    CAS  Google Scholar 

  4. Brosens, I. A., Koninckx, Ph. and Vlaemynck, G. (1979). Recovery of ovarian function in persistent hypergonadotropic state following low dose estrogen treatment. Infertility, 2, 219–26

    Google Scholar 

  5. Kim, M. H. (1974). ‘Gonadotropin resistant ovaries’ syndrome in association with secondary amenorrhea. Am. J. Obstet. Gynecol., 120, 257–62

    PubMed  CAS  Google Scholar 

  6. Koninckx, P. R. and Brosens, I. A. (1977). The gonadotropin resistant ovary syndrome as a cause of secondary amenorrhea and infertility. Fertil Steril., 28, 926–31

    PubMed  CAS  Google Scholar 

  7. Stamp, J., Selë, V. and Henriksen, B. (1971). Amenorrhea associated with increased production of gonadotropins and a morphologically normal ovarian follicular apparatus. Acta Endocrinol., 66, 248–56

    Google Scholar 

  8. Adjiman, M. (1966). Contribution à l’Étude des Ménopauses Précoces. PhD Thesis, University of Paris.

    Google Scholar 

  9. Netter, A., Lambert, A. and Rainer, S. (1966). Etude des effets des oestrogènes sur la sécrétion des ovaires humains. Rev. Eur. Endocrinol., 3, 199–209

    Google Scholar 

  10. Louvet, J. P. and Vaitukaitis, J. L. (1976). Induction of FSH receptors in rat ovaries by oestrogen priming. Endocrinology, 99, 758–64

    Article  PubMed  CAS  Google Scholar 

  11. Richards, J. S., Jonassen, J. A., Rolfes, A. I., Kersey, K. and Reichert, K. E. (1979). A.M.P., Luteinizing Hormone Receptor and progesterone during granulosa cell differentiation: effects of estradiol and follicle stimulating hormone. Endocrinology, 104, 765–73

    Article  PubMed  CAS  Google Scholar 

  12. Archer, J. A., Gorden, P., Gavin, J. R., et al. (1973). Insulin receptors in human circulating lymphocytes. J. Clin. Endocrinol. Metah., 36, 627–39

    Article  CAS  Google Scholar 

  13. Jonassen, J. A. and Richards, J. A. (1980). Granulosa cell desensitization: effects of gonadotropins on antral and preantral follicles. Endocrinology, 106, 1786–94

    Article  PubMed  CAS  Google Scholar 

  14. Pencharz, R. I. (1940). Science, 91, 954

    Article  Google Scholar 

  15. Goldenberg, R. L., Vaitukaitis, J. L. and Ross, G. T. (1972). Endocrinology, 90, 1492

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 MTP Press Limited

About this chapter

Cite this chapter

Netter, A.P., Lambert, A.E. (1984). Gonadotrophin-resistant ovaries: a desensitization syndrome?. In: de Brux, J., Gautray, JP. (eds) Clinical Pathology of the Endocrine Ovary. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-1129-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-015-1129-2_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-1131-5

  • Online ISBN: 978-94-015-1129-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics