Abstract
In the treatment of respiratory disorders, the inhaled route is an effective method for delivering drugs directly to their required site of action in the lungs and seldom results in systemic side effects. Bronchodilator, corticosteroid, mucolytic and anti-allergic agents may be given as aerosols from a variety of inhalation devices. Pressurised metered dose inhalers are widely favoured since they are highly portable, unobtrusive and supposedly easy to use. They are most frequently used to deliver β2-adrenergic stimulating agents (bronchodilators) to the lungs, these aerosols being of particular value in the treatment of asthma and bronchitis (Paterson et al. 1979).
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References
British Pharmaceutical Codex (1977) The Pharmaceutical Press, London, pp 643–648
Camner P, Philipson K (1978) Human alveolar deposition of 4 μm Teflon particles, Arch. Environ. Health 33: 181–185
Camner P, Philipson K, Linnman L (1971) A simple method for nuclidic tagging of monodisperse fluorocarbon resin particles, Int. J. Appl. Radiât. Isot. 22: 731–734
Davies D S (1975) Pharmacokinetics of inhaled substances, Postgrad. Med. J. 51 (Supplement 7): 69–75
Fuchs N A, Sutugin A G (1966) in: Davies C N (ed) Aerosol Science, Academic Press, London, pl
Gorman W G, Hall G D (1973) in: Swarbrick J (ed) Current Concepts in the Pharmaceutical Sciences: Dosage Form Design and Bioavailability, Lea and Febiger, Philadelphia, pp97–148
Heyder J, Gebhart J, Stahlhofen W (1980) in: Willeke K (ed) Generation of Aerosols and Facilities for Exposure Experiments, Ann Arbor Science, Ann Arbor, pp65–103
Hiller C, Mazumder M, Wilson D, Bone R (1978) Aerodynamic size distribution of metered-dose bronchodilator aerosols, Am. Rev. Respir. Dis. 118: 311–317
Hiller F C, Mazumder M K, Smith G M, Bone R C (1980) Physical properties, hygroscopicity and estimated pulmonary retention of various therapeutic aerosols, Chest 77 (Supplement): 318–321
May K R (1949) An improved spinning top homogeneous spray apparatus, J. Appl. Phys. 20: 932–938
Morén F (1978a) Drug deposition of pressurized inhalation aerosols I. Influence of actuator tube design, Int. J. Pharmaceutics 1: 205–212
Morén F (1978b) Drug deposition of pressurized inhalation aerosols II. Influence of vapour pressure and metered volume, Int. J. Pharmaceutics 1: 213–218
Morén F (1980) Studies on pressurized aerosols for oral inhalation, Abstracts of Uppsala Dissertations from the Faculty of Pharmacy, p33
Nilsson H T, Simonsson B G, Ström B (1976) The fate of 3H-terbutaline sulphate administered to man as an aerosol, Eur. J. Clin. Pharmacol. 10: 1–7
Paterson J W, Conolly M E, Davies D S, Dollery C T (1968) Isoprenaline resistance and the use of pressurised aerosols in asthma, Lancet 2: 426–429
Paterson J W, Woolcock A J, Shenfield G M (1979) Bronchodilator drugs, Am. Rev. Respir. Dis. 120: 1149–1188
Ruffin R E, Montgomery J M, Newhouse M T (1978) Site of beta-adrenergic receptors in the respiratory tract, Chest 74: 256–260
Stuart B O (1973) Deposition of inhaled aerosols, Arch. Intern. Med. 131: 60–73
Task Group on Lung Dynamics (1966) Deposition and retention models for internal dosimetry of the human respiratory tract, Health Phys. 12: 17 3–207
Tothill P, Gait J M (1971) Quantitative profile scanning for the measurement of organ radioactivity, Phys. Med. Biol. 16: 625–634
Walker S R, Evans M E, Richards A J, Paterson J W (1972) The fate of (14C) disodium cromoglycate in man, J. Pharm. Pharmacol. 24: 525–531
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© 1982 C.G. Wilson, J.G. Hardy, M. Frier and S.S. Davis Croom Helm Ltd, 2-10 St John’ Road, London SW11
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Newman, S.P., Pavia, D., Clarke, S.W. (1982). Therapeutic Aerosol Deposition. In: Wilson, C.G., Hardy, J.G., Frier, M., Davis, S.S. (eds) Radionuclide Imaging in Drug Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-9728-1_14
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DOI: https://doi.org/10.1007/978-94-011-9728-1_14
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