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Hodgkin’s disease; its heterogeneous nature and possible infectious aetiology

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Lymphoreticular Malignancies

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Abstract

Two issues have dominated epidemiologic studies of Hodgkin’s disease in recent years. One centres around the heterogeneous nature of this disorder, whereas the other issue deals with possible infectious aetiology in Hodgkin’s disease and the various studies used to test this hypothesis. It seems clear that these concepts are intimately related for they both deal with the question of aetiology. If Hodgkin’s disease is a single infectious disorder, the different characteristics observed for certain age groups must be explained. If the disease first described by Thomas Hodgkin in 1832 represents more than one entity, the question then becomes in which age groups is it infectious, neoplastic, etc.? The limitations of epidemiology as a scientific tool become immediately apparent when one ponders over the ways of answering these questions. For example, epidemiologic studies alone can never prove or disprove in absolute terms the hypotheses that Hodgkin’s disease is infectious in origin. The epidemiologist can however, present evidence suggesting that different age groups should be evaluated separately by the other scientific disciplines or that Hodgkin’s disease behaves as an infectious disorder under certain circumstances. In reviewing the history of this disease, the inescapable fact is that we have been asking the same basic questions since the turn of the century. We will undoubtedly go full circle again unless each scientific discipline listens to the footsteps of the other modes of inquiry. This chapter provides no definitive answers to the important aetiologic questions raised but rather it examines those studies which suggest that Hodgkin’s disease has many heterogeneous features, especially when childhood and adult cases are compared. The available evidence suggesting that this disorder might be infectious in nature is also reviewed.

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  1. Lymphoma Research Cancer Control Bureau, New York State Department of Health, Albany, New York, USA

    N. J. Vianna MD, MSPH (Director)

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Vianna, N.J. (1975). Hodgkin’s disease; its heterogeneous nature and possible infectious aetiology. In: Lymphoreticular Malignancies. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8053-5_2

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  • DOI: https://doi.org/10.1007/978-94-011-8053-5_2

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