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The Current Status of Anti-pregnancy Vaccines Based on Synthetic Fractions of HCG

  • V. C. Stevens
Chapter

Abstract

Studies conducted during the past decade suggest that immunizations resulting in the inactivation of endogenous HCG in women would be an effective means of fertility regulation1–3. The relative advantages of this approach to fertility regulation have been previously presented4 and other discussions of this subject can be found elsewhere in this volume. While this approach is very attractive, it should be emphasized that many problems must be overcome before a safe and effective method is available.

Keywords

Human Chorionic Gonadotropin Tetanus Toxoid Beta Subunit Menstrual Bleeding Immunological Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Stevens, V. C. (1974). Fertility control through active immunization using placental proteins. In Diczfalusy, E. (ed.) Immunological Approaches to Fertility Control, pp. 357–375. 7th Karolinska Symposium. Suppl. 194, Acta Endocr. (Kbh), 1915. ( Copenhagen: Bogtrykkeriet Forum )Google Scholar
  2. 2.
    Talwar, G. P., Dubey, S. K., Salahuddin, M., Das, C., Ramakrishman, S., Kumar, S. and Hingorani, V. (1976). Isoimmunization against HCG with conjugates of processed (3 subunit of the hormone and tetanus toxoid. Proc. Natl. Acad. Sci. USA, 73, 218PubMedCrossRefGoogle Scholar
  3. 3.
    Hearn, J. P. (1976). Immunization against pregnancy. Proc. R. Soc. Lond., 195, 149PubMedCrossRefGoogle Scholar
  4. 4.
    Stevens, V. C. (1978). Immunological approaches to fertility regulation. Bull. WHO, 55, 179Google Scholar
  5. 5.
    Stevens, V. C. and Crystle, C. D. (1973). Effects of immunization with hapten-coupled HCG on the human menstrual cycle. Obstet. Gynecol., 42, 485PubMedCrossRefGoogle Scholar
  6. 6.
    Vaitukaitis, J. L., Braunstein, G. D. and Ross, G. T. (1972). A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of luteinizing hormone. Am. J. Obstet. Gynecol., 113, 751PubMedGoogle Scholar
  7. 7.
    Stevens, V. C. (1976). Actions of antisera to hCG-13: in vitro and in vivo assessment. In Proceedings of the Fifth International Congress of Endocrinology, Vol. I, p. 379. ( Hamburg: Excerpta Medica International Congress Series No. 402 )Google Scholar
  8. 8.
    Das, C., Talwar, G. P., Ramakrishman, S., Salahuddin, M., Kumar, S. and Hingorani, V. (1978). Discriminatory effect of anti-Pr-(3-hCG-tt antibodies on the neutralization of the biological activity of placental and pituitary gonadotropins. Contraception, 18, 35PubMedCrossRefGoogle Scholar
  9. 9.
    Morgan, F. J., Birken, S. and Canfield, R. E. (1973). Human chorionic gonadotropin: a proposal for the amino acid sequence. Mol. Cell. Biochem., 2, 97PubMedCrossRefGoogle Scholar
  10. 10.
    Louvet, J. P., Ross, G. T., Birken, S. and Canfield, R. E. (1974). Absence of neutralizing effects of antisera to the unique structurai region of human chorionic gonadotropin. J. Clin. Endocrinol. Metab., 39, 1155PubMedCrossRefGoogle Scholar
  11. 11.
    Matsura, S., Ohashi, M., Chen, J. and Hodgen, G. (1979). A human chorionic gonadotropinspecific antiserum against synthetic peptide analogues to the carboxyl-terminal peptide of its 13-subunit. Endocrinology, 104, 396CrossRefGoogle Scholar
  12. 12.
    Chen, H., Hodgen, G. D., Matsura, S., Lin, L. J., Gross, E., Reichert, L. E., Birken, S., Canefield, R. E. and Ross, G. T. (1976). Evidence for a gonadotropin from nonpregnant subjects that has physical, immunological, and biological similarities to human chorionic gonadotropin. Proc. Natl. Acad. Sci. USA, 73, 2885PubMedCrossRefGoogle Scholar
  13. 13.
    Robertson, D. M., Suginami, H., Hernandez-Montes, H., Puri, C. P., Choi, S. K. and Diczfalusy, E. (1979). Studies on a chorionic gonadotropin-like material present in nonpregnant subjects. Acta Endocrinol., 89, 492Google Scholar
  14. 14.
    Anon (1978). Evaluating the safety and efficacy of placental antigen vaccines for fertility regulation. (Task Force on Immunological Methods for Fertility Regulation, WHO). Clin. Exp. Immunol., 33, 360Google Scholar

Copyright information

© MTP Press Limited 1980

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  • V. C. Stevens

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