Vitamin E and Muscle Diseases
Studies of the basic biochemical mechanisms underlying muscle damage aimed at finding agents which might reduce the amount of damage occurring in muscular dystrophy and other severe myopathies have been performed. These have suggested three types of agent which might be useful for this purpose, namely calcium antagonists, phospholipase inhibitors, and antioxidants or scavengers of reactive-free radicals. Vitamin E falls into the latter of these three categories and has been shown to reduce the amount of damage which occurs in isolated skeletal muscles following a given stress. It is suggested that, in the absence of calcium antagonists having relatively specific and effective actions on skeletal muscle or suitable inhibitors of muscle phospholipases in man, therapy with vitamin E or other antioxidants may reduce the amount of muscle damage occurring in patients with severe myopathies.
KeywordsMuscular Dystrophy Muscle Damage Duchenne Muscular Dystrophy Phospholipase Activity Calcium Ionophore A23187
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- Bodenstein, J. B. and Engel, A. G. Intracellular calcium accumulation in Duchenne dystrophy and other myopathies: a study of 567000 muscle fibres in 114 biopsies. Neurology 28 (1978) 439–446Google Scholar
- Diplock, A. T. The modulating influence of vitamin E in biological membrane unsaturated phospholipid metabolism. Acta Vit. Enzymol. 4 (1982) 303–309Google Scholar
- Jackson, M. J., Jones, D. A. and Edwards, R. H. T. Vitamin E and skeletal muscle. In Ciba Foundation Symposium Series No. 101. Biology of Vitamin E, Pitman Press, London, 1983, pp. 224–239Google Scholar
- Muller, D. P. R., Lloyd, J. K. and Wolf, O. H. Vitamin E and neurological function: abetalipoproteinaemia and other disorders of fat absorption. In Ciba Foundation Symposium Series No. 101. Biology of Vitamin E, Pitman Press, London, 1983, pp. 106–121Google Scholar
- Quintanilha, A. T. and Packer, L. Vitamin E, physical exercise and tissue oxidative damage. In Ciba Foundation Symposium Series No. 101. Biology of Vitamin E, Pitman Press, London, 1983, pp. 56–69Google Scholar
- Rodemann, H. P., Waxman, L. and Goldberg, A. L. The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium activated protease. J. Biol. Chem. 257 (1981) 8716–8723Google Scholar
- Soybell, D., Morgan, J. and Cohen, L. Calcium augmentation of enzyme leakage from mouse skeletal muscle and its possible site of action. Res. Commun. Chem. Pathol. Pharmacol. 20 (1978) 317–329Google Scholar