Abstract
A large number of derivatives of nitrofurfurane exhibit antibacterial properties, but few of these have been found commercially or therapeutically acceptable. Nitrofurazone is used as a cream or ointment for the topical treatment of skin, vaginal, ear or eye infections, and furazolidone has been used for the prophylaxis and treatment of gastrointestinal infections and ‘travellers’ diarrhoea’. The most widely used of these compounds is nitrofurantoin which is of value in the management of urinary tract infections.
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References
Adam, W.R. and Dawborn, J.K.: Plasma levels and urinary excretion of nalidixic acid in patients with renal failure. Australian and New Zealand Journal of Medicine 2: 126–131 (1971).
Back, O.; Lundgren, R. and Wiman, L-G.: Nitrofurantoin-induced pulmonary fibrosis and lupus syndrome. Lancet 2: 930 (1974).
Boreus, L.O. and Sundstrom, B.: Intracranial hypertension in a child during treatment with nalidixic acid. British Medical Journal 2: 744–745 (1967).
Burman, L.G.: Apparent absence of transferable resistance to nalidixic acid in pathogenic Gram-negative bacteria. Journal of Antimicrobial Chemotherapy 3: 509–516 (1977).
Finegold, S.M. and Ziment, I.: Sulfonamides, nitrofurans and nalidixic acid. Pediatric Clinics of North America 15: 95–105 (1968).
Garrod, L.P.; Lambert, H.P. and O’Grady, F.: Nalidixic acid; in Antibiotic and Chemotherapy, 4th ed, p.38–41 (Churchill Livingstone, Edinburgh and London 1973).
Goff, J.B.; Schlegel, J.U. and O’Dell, R.M.: Urinary excretion of nalidixic acid, sulfamethiazole and nitrofurantoin in patients with reduced renal function. Journal of Urology 99: 371–375 (1968).
Kucers, A.: Nitrofurantoin; in The Use of Antibiotics, p.359–367. (William Heinemann Medical Books, London 1972).
Leading Article: Pulmonary sensitivity to nitrofurantoin. British Medical Journal 4: 704 (1969).
Loughridge, L.W. Peripheral neuropathy due to nitrofurantoin. Lancet 2: 1133–1135 (1962).
Lowentritt, L.L. and Schlegel, J.U.: Treatment of bacteriuria in patients with impaired renal function. Journal of Urology 102: 473–478 (1969).
Rosenow, E.C.; De Remee, R.A. and Dines, D.E.: Chronic nitrofurantoin pulmonary reaction. Report of five cases. New England Journal of Medicine 279: 1258–1262 (1968).
Sellers, E.M. and Koch-Weser, J.: Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefenamic and nalidixic acids. Clinical Pharmacology and Therapeutics 11: 524 (1970).
Stamey, T.A., Nemoy, N.J. and Higgins, M.: The clinical use of nalidixic acid. A review and some observations. Investigative Urology 6: 582–592 (1969).
Toole, J.F.; Gergen, J.A.; Hayes, D.M. and Felts, J.H.: Neural effects of nitrofurantoin. Archives of Neurology 18: 680–687 (1968).
Wren, B.G.: Sub-clinical renal infection in pregnancy: Pathogenesis, the organisms and the drugs of choice in its treatment. Medical Journal of Australia 2: 895–898 (1969).
Zinsser, H.H.: Nalidixic acid in acute and chronic urinary tract infection. Medical Clinics of North America 54: 1347–1350(1970).
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© 1978 ADIS Press
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Ball, A.P., Gray, J.A., Murdoch, J.M. (1978). The Urinary Antiseptics. In: Antibacterial Drugs Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8004-7_12
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DOI: https://doi.org/10.1007/978-94-011-8004-7_12
Publisher Name: Springer, Dordrecht
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