Skip to main content

The Drug Treatment of Epilepsy in Pregnancy

  • Chapter
Therapeutic Problems in Pregnancy

Abstract

‘The drug treatment of epilepsy in pregnancy’—is a specific and clear title but unfortunately rather limiting in scope, particularly since Dr Roy Meadow discusses an important area in the next chapter. I propose, therefore, to expand my subject into the following areas.

  1. 1.

    Should a woman with epilepsy have children?

  2. 2.

    Is epilepsy particularly prone to start during pregnancy?

  3. 3.

    If already present, do seizures become more or less frequent during pregnancy?

  4. 4.

    What variations are there in the pharmacology of anticonvulsant drugs during pregnancy?

  5. 5.

    What risk is there of the administration of anticonvulsants to the mother resulting in intoxication of the child, either via the placenta, or via the milk?

  6. 6.

    How should status epilepticus be treated during pregnancy, and why is there a difference in the drugs used for treating status and eclampsia?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Brown, A. S. and Horton, J. M. (1967). Status epilepticus treated by intravenous infusion of thiopentone sodium. Br. Med. J., 1, 27

    Article  PubMed  CAS  Google Scholar 

  • Coradello, H. (1973). Uber die Ausscheidung von Antiepileptika in die Muttermilch. Wien. KIM. Wochensch., 85, 695

    CAS  Google Scholar 

  • Janz, D. and Schmidt, D. (1974). Antiepileptic drugs and failure of oral contraceptives. Lancet, i, 1113

    Google Scholar 

  • Knight, A. H. and Rhind, E. G. (1975). Epilepsy and pregnancy: a study of 153 pregnancies in 59 patients. Epilepsia, 16, 99

    Article  PubMed  CAS  Google Scholar 

  • Lean, T. H., Ratnam, S. S. and Sivasambro, R. (1968). Use of benzodiazepines in the management of eclampsia. J. Obstet. Grnaecol. Br. Common., 75, 856

    Article  CAS  Google Scholar 

  • Metrakos, K. and Metrakos, J. D. (1974). Genetics of epilepsy. In P. J. Vinken and G. W. Bruyn (eds.) Handbook of Clinical Neurology. ( Amsterdam: Elsevier )

    Google Scholar 

  • Pritchard, J. A. and Pritchard, S. A. (1975). Standardized treatment of 154 consecutive cases of eclampsia. Am. J. Obstet. Gynecol., 123, 543

    PubMed  CAS  Google Scholar 

  • Richens, A. (1976). Drug Treatment of Epilepsy, p. 176. ( London: Henry Kimpton )

    Google Scholar 

  • Richens, A. and Rowe, D. J. F. (1970). Disturbance of calcium metabolism by anticonvulsant drugs. Br. Med. J., 4, 73

    Article  PubMed  CAS  Google Scholar 

  • Sherwin, A. L., Loynd, J. S., Bock, G. W. and Sokolowski, C. D. (1974). Effects of age, sex, obesity, and pregnancy of plasma diphenylhydantoin levels. Epilepsia, 15, 507

    Article  PubMed  CAS  Google Scholar 

  • Somjen, G., Hilmy, M. and Stephen, C. R. (1966). Failure to anesthetize human subjects by intravenous administration of magnesium sulfate. J. Pharmacol. Exp. Therapeut., 154, 652

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 MTP Press Limited

About this chapter

Cite this chapter

Hopkins, A. (1977). The Drug Treatment of Epilepsy in Pregnancy. In: Lewis, P.J. (eds) Therapeutic Problems in Pregnancy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7927-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-7927-0_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7929-4

  • Online ISBN: 978-94-011-7927-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics