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Bile Acids in Gastroenterology pp 118–128Cite as

Biliary lipid secretion — sterol balance

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Abstract

Studies of the enterohepatic circulation (EHC) of bile acids and cholesterol are physiologically important and clinically relevant to gallstone formation and gallstone dissolution. Therefore, several methods have been developed for quantitative measurements of partial function of the EHC of biliary lipids. The analysis of cholesterol, bile acids and phospholipids in fasting gallbladder bile has given useful information on biliary lipid composition. With this method it has been demonstrated that cholesterol gallstones in man are frequently associated with supersaturated bile, i.e. bile that contains more cholesterol than can be solubilized by the bile acids and/or phospholipid content1. Administration of chenodeoxycholic (CDCA) or ursodeoxycholic acid (UDCA) reduces the molar percentage of cholesterol in bile and might thereby induce cholesterol gallstone dissolution2–4. Stone dissolution appears to be associated with a reduction in lithogenicity of bile, i.e. a reduction in concentration of cholesterol relative to the solubilizing lipids — bile acids and phospholipids. Measurement of the lithogenicity of bile before and during treatment with CDCA or UDCA as well as looking for cholesterol crystals5 will help to select patients with cholesterol gallstones for therapy and is important for dose adjustment6.

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Authors
  1. K. von Bergmann
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Editors and Affiliations

  1. Istituto di Scienze Chimiche, Facoltà di Farmacia, Univerità di Bologna, Via S. Donato 15, 40100, Bologna, Italy

    E. Roda

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© 1983 MTP Press Limited

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von Bergmann, K. (1983). Biliary lipid secretion — sterol balance. In: Barbara, L., Dowling, R.H., Hofmann, A.F., Roda, E. (eds) Bile Acids in Gastroenterology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7769-6_6

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  • DOI: https://doi.org/10.1007/978-94-011-7769-6_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7771-9

  • Online ISBN: 978-94-011-7769-6

  • eBook Packages: Springer Book Archive

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