Abstract
One of the major factors, which is clearly important in determining the fate of an allograft, is the degree of compatibility between donor and recipient at the major histocompatibility complex (MHC). In man, the MHC is referred to as HLA. It has been known for more than a decade that siblings who inherit the same HLA haplotypes from their parents, and are thus genotypically identical for HLA, are close to ideal in the very great majority of cases for donating or receiving a kidney from each other. Long-term graft survival in such instances is approximately 90%. Any degree of disparity for HLA, such as that found in siblings sharing one HLA haplotype but differing by the second, is associated with significantly decreased graft survival. The overwhelming import of matching donor and recipient for HLA is thus clearly established.
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Bach, F.H. (1982). Immunogenetics of tissue grafting. In: Castro, J.E. (eds) The Treatment of Renal Failure. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7704-7_7
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DOI: https://doi.org/10.1007/978-94-011-7704-7_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-7706-1
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