Chronic renal failure

  • V. E. Andreucci


Nephrologists may be very proud to have developed excellent techniques for replacing renal function and to have improved renal graft survival to such an extent that the kidney is the only organ for which transplantation is now a routine. Unfortunately, the same cannot be said concerning the conservative management of chronic renal failure (CRF), defined as the use of therapeutic measures other than dialysis or transplantation. When renal function is impaired because of chronic renal disease, GFR slowly and progressively declines, leading inexorably to dialysis or death. Undoubtedly chronic uraemia per se contributes to this progression through such factors as the intrarenal deposition of either uric acid, secondary to hyperuricaemia, or calcium salts, secondary to high plasma calcium x phosphorus product, and the renal damage induced by urinary tract infections which are so frequently asymptomatic, or by hypertension, which may itself be caused by CRF. Even though the correction of hypertension, the adequate treatment of urinary infections and well-balanced dietary measures cannot avoid the evolution of chronic uraemia, they may slow its progression1–3.


Chronic Renal Failure Metabolic Acidosis Secondary Hyperparathyroidism Chronic Renal Disease Renal Osteodystrophy 
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© MTP Press Limited 1982

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  • V. E. Andreucci

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