Abstract
The chemical production of hydroxyl radical, either by metal-mediated redox reactions or as a result of radiolysis products, can induce strand breaks in DNA. An example of a chemotherapeutic agent whose chemical production of activated oxygen is believed to be the critical step in its action is bleomycin, a naturally occurring antibiotic. The binding of metals to this and other antibiotics has been summarized in detail [1–3] and the material presented here is based on these reviews.
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Farrell, N. (1989). Metal-Mediated Antibiotic Action. In: Transition Metal Complexes as Drugs and Chemotherapeutic Agents. Catalysis by Metal Complexes, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7568-5_8
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DOI: https://doi.org/10.1007/978-94-011-7568-5_8
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