Skip to main content
SpringerLink
Log in

Antibacterial Effects of Metal Complexes

  • Chapter
Transition Metal Complexes as Drugs and Chemotherapeutic Agents

Part of the book series: Catalysis by Metal Complexes ((CMCO,volume 11))

  • 230 Accesses

Abstract

The almost complete elimination of debilitating and fatal bacterial diseases such as pneumonia, tuberculosis and infections arising from surgery and wounds, not to mention the reduction in the drastic consequences of bacterial epidemics, must undoubtedly be ranked as one of the major achievements of applied chemotherapy; this has been brought about by the discovery and application of the sulfonamides, penicillins and tetracyclines. The history of these discoveries is well documented and, for the sulfonamides, can be traced back to the original postulates of Paul Ehrlich at the turn of this century [1, 2]. Antimetabolites such as the sulfonamides and antibiotics, as exemplified by penicillin, have been subjected to extensive study of their structure—activity relationships and are further important in the development of systematic chemotherapy because of the recognition of clear targets associated with design of chemotherapeutic agents (for penicillin the bacterial cell wall and for sulfonamides tetrahydrofolate synthesis).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A. Albert: Selective Toxicity See Chapter 6, 6th Edition. Chapman and Hall (1979).

    Google Scholar 

  2. E. F Gale, E. Cundliffe, P. E. Reynolds, M. H. Richmond, and M. J. Waring: The Molecular Basis of Antibiotic Action See Chapter 1, 2nd Edition. Wiley (1981).

    Google Scholar 

  3. R. Koch: Mitteilungen aus dem Kaiserlichen Gesundheitsamt 234 (1881).

    Google Scholar 

  4. P. D’Arcy Hart: Brit. Med. Journal 805, (1946).

    Google Scholar 

  5. A. Castiglioni: A History of Medicine See pp. 452–460 for an historical account. A. A. Knopf (1941).

    Google Scholar 

  6. W. C. Hill: Syphilis and Local Contagious Disorders Walton (London) 1868.

    Google Scholar 

  7. W. V. Farrar and A. R. Williams: A History of Mercury (The Chemistry of Mercury, Ed. C. A. McAuliffe), pp. 3–45. Macmillan (1977).

    Google Scholar 

  8. N. Grier: Mercurials — Inorganic and Organic (Disinfection, Sterilization and Preservation, Ed. S. S. Block), pp. 346–374. Lea and Febiger (1983).

    Google Scholar 

  9. N. Grier: Silver and Its Compounds (Disinfection, Sterilization and Preservation, Ed. S. S. Block), pp. 375–389. Lea and Febiger (1983).

    Google Scholar 

  10. P. Fildes: Br. J. Exp. Pathol. 21, 67 (1940).

    CAS  Google Scholar 

  11. A. Cremieux et al.: Ann. Pharm. Franc. 37, 101 and 165 (1979).

    CAS  Google Scholar 

  12. M. Schaecter and K. A. Santomassino: J. Bacteriol. 84, 325 (1962).

    Google Scholar 

  13. J. L. Webb: The Mercurials Vol. II, pp. 729–1070. Academic Press (1966).

    Google Scholar 

  14. M. Cortat: Zentralb. Bakteriol., Abt. Orig. B, 166, 517–539 (1978); C.A. 89: 141111m.

    CAS  Google Scholar 

  15. D. B. Millar: Biochem. Biophys. Res. Comm. 28, 70 (1967).

    Article  CAS  Google Scholar 

  16. C. A. Moyer et al.: Arch. Surg. 90, 812 (1965).

    Article  CAS  Google Scholar 

  17. C. L. Fox: Arch. Surg. 96, 184 (1968).

    Article  Google Scholar 

  18. A. Bult: Pharm. Int. 3, 400 (1982).

    Google Scholar 

  19. D. A. Cook and M. F. Turner: J. Chem. Soc. (Perkin Trans.) 2, 1021 (1975).

    Article  Google Scholar 

  20. L. G. Marzilli, T. J. Kistenmacher, and M. Rossi: J. Am. Chem. Soc. 99, 2797 (1977).

    Article  CAS  Google Scholar 

  21. S. M. Modak and C. L. Fox: Biochem. Pharmacol. 3, 2391 (1973).

    Article  Google Scholar 

  22. C. L. Fox and S. M. Modak: Antimicr. Ag. Chemother. 5, 582 (1974).

    CAS  Google Scholar 

  23. J. E. Coward, H. S. Carr, and H. S. Rosenkranz: Antimicr. Ag. Chemother. 3, 621 (1973).

    CAS  Google Scholar 

  24. M. S. Wysor and R. E. Zollinhofer: Pathol. Microbiol. 39, 434 (1973).

    CAS  Google Scholar 

  25. M. S. Wysor and R. E. Zollinhofer: Chemotherapy 17, 188 (1972).

    Article  CAS  Google Scholar 

  26. S. Yamashita, Y. Seyama, and N. Ishikawa: Experientia 34, 472 (1978).

    Article  CAS  Google Scholar 

  27. A. Bult: Pharm. Weekbl. 3, 1(1981).

    Article  Google Scholar 

  28. A. Shulman and F. P. Dwyer: Metal Chelates in Biological Systems (Chelating Agents and Metal Chelates, Eds. F. P. Dwyer and D. P. Mellor), p. 383. Academic Press (1964).

    Google Scholar 

  29. F. P. Dwyer, I. K. Reid, A. Shulman, G. M. Laycock, and S. Dixson: Aust. J. Exp. Biol. Med. Sci. 47, 203 (1969).

    Article  CAS  Google Scholar 

  30. H. M. Butler, A. Hurse, E. Thursky, and A. Shulman: Aust. J. Exp. Biol. Med. Sci. 47, 541 (1969).

    Article  CAS  Google Scholar 

  31. H. Smit, H. van der Goot, W. T. Nauta, P. J. Pijper, S. Balt, M. W. G. de Bolster, A. H. Stouthamer, H. Verheul, and R. D. Vis: Antimicr. Ag. Chemother. 18, 249 (1980).

    CAS  Google Scholar 

  32. J. Youatt: Aust. J. Expl. Biol. Med. Sci. 40, 201 (1962).

    Article  CAS  Google Scholar 

  33. J. Seydel, K. Schaper, E. Wempe, and H. Cordes: J. Med. Chem. 19, 483 (1976).

    Article  CAS  Google Scholar 

  34. J. B. Neilands and J. R. Valenta: Metal Ions in Biol. Syst. 19, 313 (1985).

    CAS  Google Scholar 

  35. G. Benz, T. Schroder, J. Kurz, C. Wunsche, W. Karl, G. Steffens, J. Pfitzner, and D. Schmidt: Angew. Chem. Suppl. 1322 (1982).

    Google Scholar 

  36. R. J. Bromfield, R. H. Dainty, R. D. Gillard, and B. T. Heaton: Nature 223, 735 (1969).

    Article  CAS  Google Scholar 

  37. R. D. Gillard: Kem. Kozlemenyek 47, 107 (1977).

    Google Scholar 

  38. T. R. Jack: J. Inorg. Biochem. 12, 187 (1980).

    Article  CAS  Google Scholar 

  39. R. D. Gillard: Heavy Metals in Medicine (New Trends in Bioinorganic Chemistry, Eds. R. J. P. Williams and J. R. R. F. da Silva), p. 355. Academic Press (1978).

    Google Scholar 

  40. B. Rosenberg, L. vanCamp, and T. Krigas: Nature 205, 698 (1965).

    Article  CAS  Google Scholar 

  41. B. Rosenberg, L. vanCamp, E. B. Grimley, and A. J. Thomson: J. Biol. Chem. 242, 1347 (1967).

    CAS  Google Scholar 

  42. J. Drobnik, M. Urbankova, and A. Krekulova: Mutation Res. 17, 13 (1973).

    Article  CAS  Google Scholar 

  43. D. J. Beck and R. R. Brubaker: J. Bacteriol. 116, 1247 (1973).

    CAS  Google Scholar 

  44. B. Rosenberg, E. Renshaw, L. vanCamp, J. Hartwick, and J. Drobnik: J. Bacteriol. 93, 716 (1967).

    CAS  Google Scholar 

  45. M. J. Cleare: in Reference 46, pp. 29–34.

    Google Scholar 

  46. Recent Results in Cancer Research (Eds. T. A. Connors and J. J. Roberts, v. 48). Springer-Verlag (1974).

    Google Scholar 

  47. I. Fridovich: New Eng. J. Med. 290, 624 (1974).

    Article  CAS  Google Scholar 

  48. B. M. Babior: Superoxide and Oxidative Killing by Phagocytes (The Biology and Chemistry of Active Oxygen, Eds. J. V. Bannister and W. H. Bannister) pp. 190–207. Elsevier, New York (1984).

    Google Scholar 

  49. H. N. Yeowell and J. R. White: Antimic. Ag. Chemother. 22, 961 (1982).

    CAS  Google Scholar 

  50. R. M. Hassan and I. Fridovich: J. Bacteriol. 129, 1574 (1977).

    CAS  Google Scholar 

  51. J. E. Repine, R. B. Fox, and E. M. Berger: J. Biol. Chem. 256, 7094 (1981).

    CAS  Google Scholar 

  52. A. J. Salle: Heavy Metals other than Mercury and Silver (Disinfection, Sterilization, and Preservation, Ed. S. S. Block) pp. 390–398. Lea and Febiger (1983).

    Google Scholar 

  53. D. B. Drath and M. L. Karnovsky: Infect. Immun. 10, 1077 (1974).

    CAS  Google Scholar 

  54. B. S. van Asbeck, J. H. Marcelis, J. H. van Kats, E. Y. Jaarsma, and J. Verhoef: Eur. J. Clin. Microbiol. 2, 426 (1983).

    Article  Google Scholar 

  55. J. R. J. Sorenson: Prog. Med. Chem. 15, 211 (1978).

    Article  CAS  Google Scholar 

  56. P. A. Simkin: Lancet 539 (1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The University of Vermont, Burlington, Vermont, USA

    Nicholas Farrell

Authors
  1. Nicholas Farrell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Farrell, N. (1989). Antibacterial Effects of Metal Complexes. In: Transition Metal Complexes as Drugs and Chemotherapeutic Agents. Catalysis by Metal Complexes, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7568-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-7568-5_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7570-8

  • Online ISBN: 978-94-011-7568-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation