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Immunological Aspects

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Heart Transplantation

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Abstract

Since numerous detailed accounts of transplantation immunology appear elsewhere in the literature1–3, this chapter will concentrate only on those immunological aspects of cardiac transplantation that are of practical clinical importance today. Five important topics will be discussed: (1) the necessity for donor-recipient ABO blood group compatibility, (2) the role of human leukocyte antigen (HLA) matching, (3) the lymphocytotoxic cross-match test and the problem of preformed antibodies, (4) the value of pretransplant blood transfusions in recipients of cardiac allografts, and (5) the mechanism of allograft destruction.

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Authors
  1. E. D. du Toit
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  2. R. P. Lanza
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Editors and Affiliations

  1. Groote Schuur Hospital and the University of Cape Town Medical School, Cape Town, South Africa

    D. K. C. Cooper MA, MB, BS, PhD, FRCS (Specialist in Cardiothoracic Surgery) (Specialist in Cardiothoracic Surgery)

  2. Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, University of Cape Town Medical School, Cape Town, South Africa

    R. P. Lanza MD (Chris Barnard Fund Research Fellow) (Chris Barnard Fund Research Fellow)

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© 1984 MTP Press Limited

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du Toit, E.D., Lanza, R.P. (1984). Immunological Aspects. In: Cooper, D.K.C., Lanza, R.P. (eds) Heart Transplantation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7324-7_6

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  • DOI: https://doi.org/10.1007/978-94-011-7324-7_6

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