Abstract
The brain damage which results from a combination of systemic hypoxia and reduced cerebral blood flow (ischemia) in the fetus and newborn infant remains a major cause of chronic neurological disability. Hypoxia denotes a partial lack of oxygen with or without concurrent accumulation of carbon dioxide. Asphyxia is that state in which pulmonary or placental gas exchange ceases, resulting in progressive hypoxemia or anoxemia combined with hypercapnia. Ischemia is a reduction in or cessation of blood flow. It rarely occurs during the perinatal period without antecedent hypoxia or asphyxia.
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Vannucci, R.C. (1985). Pathogenesis of Perinatal Hypoxic-Ischemic Brain Damage. In: Thompson, R.A., Green, J.R., Johnsen, S.D. (eds) Perinatal Neurology and Neurosurgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7295-0_2
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DOI: https://doi.org/10.1007/978-94-011-7295-0_2
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