Lithium Non-Responders and their Treatment

  • Athanasio Kukopulos
  • Leonardo Tondo

Abstract

Since the first trials of lithium as a prophylactic treatment against manic-depressive recurrences1, it has been clear that a certain number of patients do not show substantial improvement under continuous lithium treatment. This does not lessen the value of the prophylactic efficacy of lithium, because a much larger number of patients improve enormously under this treatment. The patients that respond poorly to lithium are nevertheless a serious problem, since their form of the disease is among the severest and they are most in need of an effective prophylaxis. As a great many lithium non-responders have very frequent recurrences, other treatments that act only upon a single episode are almost useless, because after having been treated for one episode, the patients are shortly sick again in a new episode. For these patients a lithium prophylaxis failure is a bitter disappointment, and it leaves the physician without alternatives.

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References

  1. 1.
    Baastrup, P. C. and Schou, M. (1967). Lithium as a prophylactic agent. Its effect against depression and manic-depressive psychosis. Arch. Gen. Psychiat., 16, 162–172.PubMedCrossRefGoogle Scholar
  2. 2.
    Kukopulos, A., Reginaldi, D., Girardi, P. and Tondo, L. (1975). Course of manic-depressive recurrences under lithium. Compr. Psychiat., 16, 517–524.PubMedCrossRefGoogle Scholar
  3. 3.
    Dunner, D. L. and Fieve, R. R. (1974). Clinical factors in lithium carbonate prophylaxis failure. Arch. Gen. Psychiat., 30, 229–233.PubMedCrossRefGoogle Scholar
  4. 4.
    Prien, R. F., Caffey, E. M. and Klett, C. J. (1974). Factors associated with treatment success in lithium carbonate prophylaxis. Arch. Gen. Psychiat., 31, 189–192.PubMedCrossRefGoogle Scholar
  5. 5.
    Dunner, D. L., Fleiss, J. L. and Fieve, R. R. (1976). Lithium carbonate prophylaxis failure. Br. J. Psychiat., 129, 40–44.CrossRefGoogle Scholar
  6. 6.
    Misra, P. C. and Burns, B. H. (1977). ‘Lithium non-responders’ in a lithium clinic. Acta Psychiat. Scand., 55, 32–40.PubMedCrossRefGoogle Scholar
  7. 7.
    Ananth, J. and Pecknold, J. C. (1978). Prediction of lithium response in affective disorders. J. Clin. Psychiat., 39, 95–100.Google Scholar
  8. 8.
    Grof, P., Lane, J., MacCrimmon, D., Werstiuk, E., Blajchman, M., Daigle, L. and Varma, R. (in press). Clinical and laboratory correlates of the response to long-term lithium treatment.Google Scholar
  9. 9.
    Van der Velde, C. D. (1970). Effectiveness of lithium carbonate in the treatment of manic-depressive illness. Am. J. Psychiat., 127, 345–351.PubMedGoogle Scholar
  10. 10.
    Kukopulos, A. and Reginaldi, D. (1973). Does lithium prevent depressions by suppressing manias? Internat. Pharmacopsychiat., 8, 152–158.Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • Athanasio Kukopulos
  • Leonardo Tondo

There are no affiliations available

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