Lithium Non-Responders and their Treatment
Since the first trials of lithium as a prophylactic treatment against manic-depressive recurrences1, it has been clear that a certain number of patients do not show substantial improvement under continuous lithium treatment. This does not lessen the value of the prophylactic efficacy of lithium, because a much larger number of patients improve enormously under this treatment. The patients that respond poorly to lithium are nevertheless a serious problem, since their form of the disease is among the severest and they are most in need of an effective prophylaxis. As a great many lithium non-responders have very frequent recurrences, other treatments that act only upon a single episode are almost useless, because after having been treated for one episode, the patients are shortly sick again in a new episode. For these patients a lithium prophylaxis failure is a bitter disappointment, and it leaves the physician without alternatives.
KeywordsAntidepressant Drug Lithium Treatment Good Responder Lithium Level Lithium Dose
Unable to display preview. Download preview PDF.
- 7.Ananth, J. and Pecknold, J. C. (1978). Prediction of lithium response in affective disorders. J. Clin. Psychiat., 39, 95–100.Google Scholar
- 8.Grof, P., Lane, J., MacCrimmon, D., Werstiuk, E., Blajchman, M., Daigle, L. and Varma, R. (in press). Clinical and laboratory correlates of the response to long-term lithium treatment.Google Scholar
- 10.Kukopulos, A. and Reginaldi, D. (1973). Does lithium prevent depressions by suppressing manias? Internat. Pharmacopsychiat., 8, 152–158.Google Scholar