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Combinations of antibacterial drugs

  • N. A. Simmons
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Part of the Current Status of Modern Therapy book series (CSMT, volume 4)

Abstract

A few years ago I carried out a survey in a hospital in which I was then working and found that sufficient antibiotics were being dispensed by the pharmacy to maintain half of the patients in the hospital on antibiotics for the duration of their stay. However, on closer inspection it was apparent that fewer patients were receiving several antibacterial drugs and occasionally as many as three simultaneously. The reasons for the treatment were not always sound and combinations were sometimes given on the basis that two antibiotics were bound to be better than one. Similarly, the Lancet recently estimated that as many as one fifth of patients in hospital with infections receive two or more antibacterial agents concurrently1. The value of commercial preparations of fixed combinations of drugs is suspect2 and in the past the sale of some combinations has been banned in the United States by the Food. and Drug Administration3. Nevertheless, in Great Britain MIMS (the Monthly Index of Medical Specialities) lists in its sections on antibiotics, sulphonamides and antibacterials no fewer than 11 commercially available mixtures of antibacterial agents and, presumably, the pharmaceutical companies are not in the habit of producing preparations for which there is no demand.

Keywords

Antibacterial Agent Nalidixic Acid Serratia Marcescens Antibacterial Drug Fusidic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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