Abstract
Weakness and tiring easily are the most common symptoms of surgical convalescence. This response is more severe and prolonged than the associated bed-rest and decreased nutrition can account for. A prominent feature of acute surgical catabolism is an obligatory negative nitrogen balance, associated with protein breakdown. Despite the repeated confirmation of these findings since the first reports in 1930, the underlying mechanism and physiological significance remains obscure. The observed clinical weakness and fatigue may be the result of the negative nitrogen balance which is largely due to the breakdown of muscle protein.
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Fürst, P., Bergström, J., Vinnars, E., Schildt, B., Holmström, B. (1978). Intracellular amino acids and energy metabolism in catabolic patients with regard to muscle tissue. In: Johnston, I.D.A. (eds) Advances in Parenteral Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7188-5_6
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DOI: https://doi.org/10.1007/978-94-011-7188-5_6
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