Abstract
Within the last decade several symposia have dealt with parenteral nutrition1–6. My own experiences relating to the subject stem, apart from studies of intermediary metabolism, from the ‘feeding’ of isolated organs in laboratory experiments. In studying metabolism and its regulation we have made much use of isolated perfused organs, especially the liver, kidney, heart and the hind-limb of rats (the latter presenting mainly the musculature). More recently we have also used isolated hepatocytes whose metabolic competence is almost identical with that of the intact perfused organ7. In such experiments it is essential to ‘feed’ the organs in order to keep them in a normal functional state. This means in the first instance supplying a source of energy in the form either of carbohydrate, or carbohydrate derivatives, or fatty acids or ketone bodies. It may also be essential to provide special blood plasma constituents such as amino acids or hormones8,9. These experiences, then, are my credentials for participating in this Symposium. They imply that I must limit myself to comments on principles derived from basic biochemistry.
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Krebs, H.A. (1978). Some general considerations concerning the use of carbohydrates in parenteral nutrition. In: Johnston, I.D.A. (eds) Advances in Parenteral Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7188-5_2
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DOI: https://doi.org/10.1007/978-94-011-7188-5_2
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