Abstract
Since the reports by Vane1 as well as Smith and Willis2 that aspirin and indomethacin are potent inhibitors of prostaglandin synthetase, there has been a controversy concerning the role of such non-steroidal anti-inflammatory agents (NSAI) in inflammatory processes. Other studies demonstrated a reasonable correlation between the action of NSAI on PG synthetase and activity both in the rat paw carrageenan assay and the clinic3–5. Nevertheless, the failure of administered PGEs and PGFs to fully mimic the symptoms of inflammation did not foster this interpretation6,7.
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References
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Kuehl, F.A., Humes, J.L., Egan, R.W. (1977). Evidence for a pivotal role of the endoperoxide, PGG2, in inflammatory processes. In: Willoughby, D.A., Giroud, J.P., Velo, G.P. (eds) Perspectives in Inflammation. Future Trends in Inflammation, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7185-4_25
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DOI: https://doi.org/10.1007/978-94-011-7185-4_25
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