Abstract
The assumption has been made that if elevated lipid levels (mainly cholesterol) are lowered, the atherosclerosis risk rate will be decreased as well. Though eminently logical, this lipid-atherosclerosis hypothesis still requires rigorous, statistically sound proof. To this end, several large national and international clinical intervention trials have been funded. One, a secondary intervention trial, utilizes the partial ileal bypass operation as the means for cholesterol lowering. Until the lipid-atherosclerosis hypothesis is confirmed or denied by clinical trial, we believe judicious and rational hyperlipidemia management is indicated, in the light of current knowledge.
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References
Balfour, J.F. and Kim, R. Homozygous type II hyperlipoproteinemia treatment, partial ileal bypass in two children. JAMA 227, 1145–1151 (1974).
Baltaxe, H., Amplatz, K., Varco, R.L., and Buchwald, H. Coronary arteriography in hypercholesterolemic patients. Am. J. Roent 105, 784–790 (1969).
Buchwald, H. Localization of cholesterol absorption. Circulation 28 (suppl. 2), 649 (1963a).
Buchwald, H. Surgical operation to lower circulating cholesterol. Circulation 28 (suppl. 2), 649 (1963b).
Buchwald, H. Lowering of cholesterol absorption and blood levels by ileal exclusion: Experimental basis and preliminary clinical report. Circulation 29, 713–720 (1964).
Buchwald, H. The effect of ileal bypass on atherosclerosis and hypercholesterolemia in the rabbit. Surgery 58, 22–36 (1965a).
Buchwald, H. Myocardial infarction in rabbits induced solely by a hypercholesterolemic diet. J. Atheroscler. Res. 4, 407–419 (1965b).
Buchwald, H. and Gebhard, R. Effect of intestinal bypass on cholesterol absorption and blood levels in the rabbit. Am. J. Physiol 207, 567–572 (1964).
Buchwald, H. and Gebhard, R.L. Localization of bile salt absorption in-vivo in the rabbit. Ann. Surg. 167, 191–198 (1968).
Buchwald, H. and Varco, R.L. Partial ileal bypass for hypercholesterolemia and atherosclerosis. Surg. Gyn. Obst. 124, 1231–1238 (1967).
Buchwald, H., Moore, R.B., and Varco, R.L. Surgical treatment of hyperlipidemia. Circulation 49 (suppl. 1), 1–35 (1974).
Buchwald, H., Moore, R.B., Bertish, J., and Varco, R.L. Effect of ileal bypass on cholesterol levels, atherosclerosis and growth in the infant rabbit. Ann. Surg. 175, 311–319 (1972).
Buchwald, H., Varco, R.L., Moore, R.B., and Schwartz, M.Z. Intestinal bypass procedures: Partial ileal bypass for hyperlipidemia and jejuno-ileal bypass for obesity. Curr. Prob. Surg, April (1975), pp. 1–51.
Coyle, J. J., Varco, R.L., and Buchwald, H. Effect of bile acids on hepatic cholesterol synthesis in partial ileal bypass in rabbits. Surg. Forum 27, 447–448 (1976).
Frost, J.W., Finch, W.T., Younger, R., Butts, W.H., Scott, H.W., Jr. Pilot study of the therapeutic effects of ileal bypass in dogs with experimentally established hypercholesterolemia and atherosclerosis. Surg. Forum 21, 398–399 (1970).
Gebhard, R.L., and Buchwald, H. Cholesterol absorption after reversal of the upper and lower halves of the small intestine. Surgery 67, 474–477 (1970).
Gomes, M.M., Kottke, B.A., Bernatz, P., and Titus, J.L. Effect of ileal bypass on aortic atherosclerosis of White Carneau pigeons. Surgery 70, 353–358 (1971).
Knight, L., Scheibel, R., Amplatz, K., Varco, R.L., and Buchwald, H. A radiographic appraisal of the Minnesota partial ileal bypass study. Surg. Forum 23, 141–142 (1972).
Moore, R.B., Frantz, I.D., Jr., and Buchwald, H. Changes in cholesterol pool size, turnover rate, and fecal bile acid and sterol excretion after partial ileal bypass in hypercholesterolemic patients. Surgery 65, 98–108 (1969).
Moore, R.B., Frantz, I.D., Jr., Varco, R.L., and Buchwald, H. Cholesterol dynamics after partial ileal bypass, in Proceedings of the Second International Symposium on Atherosclerosis. R.J. Jones, ed. Springer-Verlag, New York (1970), pp. 295–300.
Scott, H.W., Jr., Stephenson, S.E., Jr., Younger, R., Carlisle, B.B., and Turney, S.W. Prevention of experimental atherosclerosis by ileal bypass: Twenty percent cholesterol diet and I131 -induced hypothyroidism in dogs. Ann. Surg. 163, 795–807 (1966).
Shepard, G.H., Wimberly, J.E., Younger, R., Stephenson, S.E., Jr., and Scott, H.W., Jr. Effects of bypass of the distal third of the small intestine on experimental hypercholesterolemia and atherosclerosis in rhesus monkeys. Surg. Forum 19, 302–303 (1968).
Younger, R., Shepard, G.H., Butts, W.H., and Scott, H.W., Jr. Comparison of the protective effects of cholestyramine and ileal bypass in Rhesus monkeys on an atherogenic regimen. Surg. Forum 20, 101–102 (1969).
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Buchwald, H., Varco, R.L. (1982). Management of Hypercholesterolemia by Partial Ileal Bypass. In: Naito, H.K. (eds) Nutrition and Heart Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6692-8_14
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DOI: https://doi.org/10.1007/978-94-011-6692-8_14
Publisher Name: Springer, Dordrecht
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