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A randomized study of metabolic effects of four oral contraceptive preparations containing levonorgestrel plus ethinyloestradiol in different regimens

  • M. Briggs
  • M. Briggs

Abstract

Healthy, normotensive, well-motivated, young women were assigned at random to one of four oral contraceptives containing levonorgestrel plus ethinyloestradiol (21-day cyclic treatments) and 80 completed six treatment cycles. Metabolic and endocrine status tests were conducted in the pretreatment cycle and at intervals during the study. All four products appeared to be equally efficient inhibitors of ovulation, as judged by plasma hormone indices. Deterioration of oral glucose tolerance and insulin responses were noted with all preparations, except a triphasic formulation. All products increased the concentration of triglycerides in fasting plasma, though the extent of the increase appeared to be dose-related. Only the highest dose product significantly increased plasma cholesterol. Cholesterol in high-density lipoproteins was significantly increased by an oestrogenic biphasic product, but significantly decreased by a high-dose fixed combination. Significant increases in fibrinogen, plasminogen, and coagulation factors VII, VIII and X were observed, especially with the highest dose product and the oestrogen-dominated biphasic. Antithrombin III was suppressed. Renin activity and renin-substrate concentration were elevated, while plasma renin concentration was reduced: again the effects appeared to be related to the oestrogen dose.

Keywords

Luteinizing Hormone Oral Contraceptive Renin Activity Oral Contraceptive User Plasma Renin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. Briggs
  • M. Briggs

There are no affiliations available

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