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Clinical and experimental aspects of prenatal virus infections

  • Chapter
Teratological Testing

Part of the book series: Advances in the Study of Birth Defects ((ASBD,volume 2))

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Abstract

In his address to the University of Chicago in 1942, the late Dr Ernest Goodpasture emphasized that cells of the avian embryo or mammalian fetus were significantly more susceptible to microbiological infections than those of the adult1. He showed that vaccinia and herpes simplex viruses lead to widely disseminated infections in the embryo or fetus but caused only mild lesions in the adult. Although Goodpasture was unable to explain this greater susceptibility of embryonic tissue to some infections, he suggested that the young and relatively undifferentiated cells formed more propitious media for viral replication, probably on account of their higher metabolic rate and absence of effective immunological systems.

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    T. V. N. Persaud

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Lansdown, A.B.G. (1979). Clinical and experimental aspects of prenatal virus infections. In: Persaud, T.V.N. (eds) Teratological Testing. Advances in the Study of Birth Defects, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6651-5_16

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