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Polymorphonuclear Leukocytes (PMN)—Origins, Functions and Roles in the Rheumatic Diseases

  • Chapter
Immunological Aspects of Rheumatology

Abstract

It is over 200 years since the English surgeon, William Hewson1, first described the white blood cells. A little more than 100 years were to pass before Elie Metchnikoff, the famous Russian biologist working in France, observed and appreciated that the phagocytic white cell is capable of intracellular killing of bacteria. He realized that this was done by intracellular cytases (lysomal enzymes) and he felt that these cytases might also be capable of provoking inflammation2; however, he thought that they were mainly released by dead and dying cells. It was not until the last 15 years or so that the molecular basis for these events began to be understood. In recent years the volume of literature in this area of physiology has grown exponentially. This review will therefore not aim to be an exhaustive examination of all available literature but will attempt to summarize areas where a general consensus has been reached and to provide an overview of current thoughts on the role of the polymorph in the pathophysiology of some of the rheumatic diseases.

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Authors
  1. G. B. Howe
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  2. J. N. Fordham
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Editors and Affiliations

  1. University Department of Rheumatology, The Royal Victoria Infirmary, Newcastle upon Tyne, UK

    W. Carson Dick

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Howe, G.B., Fordham, J.N. (1981). Polymorphonuclear Leukocytes (PMN)—Origins, Functions and Roles in the Rheumatic Diseases. In: Dick, W.C. (eds) Immunological Aspects of Rheumatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6624-9_7

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  • DOI: https://doi.org/10.1007/978-94-011-6624-9_7

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