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The measurement of liver injury and protection, with special reference to paracetamol, dimethylnitrosamine and carbon tetrachloride

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Pathogenesis and Mechanisms of Liver Cell Necrosis

Abstract

Paracetamol (N. acetyl para-ammo phenol, acetaminophan ‘Panadol’, and many other trade names in USA, Germany and elsewhere) is a safe and effective analgesic, used like aspirin, but without aspirin’s gastric irritant effect. It was well-described in 18941 and is practically without side-effects in normal use. However in gross overdose (12–50 g in man) it causes severe liver damage2. In 1973 there were about 5000 cases of self-poisoning with paracetamol in Britain, with 50 deaths (R. Goulding, Poisons Centre, Guy’s Hospital, London, personal communication).

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References

  1. Hinsberg, O., Treupel, G. (1894). Ueber die Physiologische Wirkung des p-Amido phenols und einiger Derivative Desselben. Arch. Exp. Pathol., 33, 216–250

    Article  Google Scholar 

  2. Prescott, L. F., Wright, N., Roscol, P., Brown, S. S. (1971). Plasma paracetamol half life and hepatic necrosis in patients with paracetamol overdosage. Lancet, i, 519–522

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  3. Williams, R. T. (1959). Detoxication Mechanisms, 328 (London: Chapman and Hall)

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  4. Mitchell, J. R., Thorgeiresson, S. S., Potter, W. Z., Jollow, D. J., Keiser, H. (1974). Acetaminophen induced hepatic injury: Protective role of gluthathione in man and rationale for therapy. Clin. Pharmacol. Ther., 16, 676–684.

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  5. McLean, A. E. M., Day, P. A. (1975). The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures. Biochem. Pharmacol., 25, 37–42.

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  6. McLean, A. E. M., Day, P. A. (1974). The use of new methods to measure the effect of diet and inducers of microsomal enzyme synthesis of cytochrome P450 in liver homogenates and a metabolism of dimethyl nitrosamine. Biochem. Pharmacol., 23, 1173–1180

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Authors
  1. A. E. M. McLean
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Editors and Affiliations

  1. Biochemisches Institut, University of Freiburg im Breisgau, Deutschland

    D. Keppler

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© 1975 D. Keppler

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McLean, A.E.M. (1975). The measurement of liver injury and protection, with special reference to paracetamol, dimethylnitrosamine and carbon tetrachloride. In: Keppler, D. (eds) Pathogenesis and Mechanisms of Liver Cell Necrosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6618-8_12

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  • DOI: https://doi.org/10.1007/978-94-011-6618-8_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6620-1

  • Online ISBN: 978-94-011-6618-8

  • eBook Packages: Springer Book Archive

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