Abstract
It has been shown (Jones and Waldman, 1972) that rat IgG binds to isolated neonatal rat brushborders. These workers have also shown that binding is pH dependent, maximal binding occurring at pH 6.5. It is suggested that binding may be the selective process by which preferential transport of IgG from the gut lumen to the serum of the newborn occurs. The present preliminary studies are concerned with examining the kinetics of binding of rat and bovine IgG to isolated brushborders prepared from neonatal rat jejunum.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Forstner, G. G., Sabesin, S. M. and Isselbacher, K. J. (1968). Rat intestinal microvillus membranes. Purification and Biochemical characterization. Biochem. J., 106, 381
Jones, E. A. and Waldmann, T. A. (1972). The mechanism of uptake and transcellular transport of IgG in the neonatal rat. J. Clin. Invest., 51, 2916
Morris, I. G. (1957). The effect of heterologous sera on the uptake of rabbit antibody from the gut of young mice. Proc. R. Soc. B, 148, 84
Rosa, U., Scasscellati, G. A., Pennisi, F., Riccioni, N., Giagnoni, P. and Giordoni, R. (1964). Labelling of human fibrinogen with iodine-131 by electrolytic iodination Biochim. Biophys. Acta, 86, 519
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 MTP Press Limited
About this chapter
Cite this chapter
Gingles, R. (1978). A preliminary study of the binding of rat and bovine IgG to isolated brushborders from neonatal rat jejunum. In: Hemmings, W.A. (eds) Antigen Absorption by the Gut. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6609-6_4
Download citation
DOI: https://doi.org/10.1007/978-94-011-6609-6_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6611-9
Online ISBN: 978-94-011-6609-6
eBook Packages: Springer Book Archive