Abstract
Brambell (1970) has thoroughly reviewed the investigations carried out up to 1968 on the transmission of passive immunity from mother to young in mammals, and consideration of the results pertaining to the rabbit and rodents enabled the formulation of the Brambell Receptor Hypothesis. Until then, the development of this hypothesis had spanned two decades, the first of which culminated in 1958 with the statement of the hypothesis in its original form (Brambell, Halliday and Morris, 1958). The second decade saw several restatements of the hypothesis in the light of new evidence (Brambell, 1963; Brambell, Hemmings and Morris, 1964; Brambell, 1966), and terminated in 1970 with a full evaluation of the hypothesis (Brambell, 1970). At that time, the originator of the hypothesis believed that it left many questions unanswered and would inevitably have to be modified and adapted to further advances.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bamford, D. R. (1966). Studies in vitro of the passage of serum proteins across the intestinal wall of young rats. Proc. R. Soc. B, 166, 30
Brambell, F. W. R. (1958). The passive immunity of the young mammal. Biol. Rev., 33, 488
Brambell, F. W. R. (1963). Resemblances between passive anaphylactic sensitization and transmission of passive immunity. Nature, Lond., 199, 1164
Brambell, F. W. R. (1966). The transmission of immunity from mother to young and the catabolism of immunoglobulins. Lancet, ii, 1087
Brambell, F. W. R. (1970). The transmission of passive immunity from mother to young. Frontiers of Biology, Vol. 18. (Amsterdam: North Holland)
Brambell, F. W. R., Halliday, R. and Hemmings, W. A. (1961). Changes in iodine-131 labelled immune bovine gamma-globulin during transmission to the circulation after oral administration to the young rat. Proc. R. Soc. B, 153, 477
Brambell, F. W. R., Halliday, R. and Morris, I. G. (1958). Interference by human and bovine serum protein fractions with the absorption of antibodies by suckling rats and mice. Proc. R. Soc. B, 149, 1
Brambell, F. W. R., Hemmings, W. A. and Morris, I. G. (1964). A theoretical model of gamma-globulin catabolism. Nature, Lond., 203, 1352
Brambell, F. W. R., Hemmings, W. A., Oakley, C. L. and Porter, R. R. (1960). The relative transmission of the fractions of papain hydrolysed homologous gamma-globulin from the uterine cavity to the foetal circulation in the rabbit. Proc. Roy. Soc. B, 151, 478
Clark, S. L. (1959). The ingestion of proteins and colloidal materials by columnar absorptive cells of the small intestine in suckling rats and mice. J. Biophys. Biochem. Cytol., 5, 41
Edelman, G. M. (1959). Dissociation of gamma-globulin. J. Am. Chem. Soc., 81, 3155
Elson, J., Jenkinson, E. J. and Billington, W. D. (1975). Fc receptors on mouse placenta and yolk sac cells. Nature, Lond., 255, 412
Gitlin, J. D. and Gitlin, D. (1976). Protein binding by cell membranes and the selective transfer of proteins from mother to young across tissue barriers. In: (W. A. Hemmings (ed.), Maternofoetal Transmission of Immunoglobulins p.113–119. (London: Cambridge University Press)
Graney, D. O. (1968). The uptake of ferritin by ileal absorptive cells in suckling rats. An electron microscope study. Am. J. Anat., 123, 227
Halliday, R. (1959). The effect of steroid hormones on the absorption of antibody by the young rat. J. Endocrinol., 18, 56
Hemmings, W. A. (1957). Protein selection in the yolk-sac splanch-nopleur of the rabbit: the total uptake estimated as loss from the uterus. Proc. R. Soc. B, 148, 76
Hemmings, W. A. and Oakley, C. L. (1957). Protein selection in the yolk-sac splanchnopleur of the rabbit: the fate of globulin injected into the foetal circulation. Proc. R. Soc. B, 146, 573
Jones, E. A. and Waldmann, T. A. (1972). The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J. Clin. Invest., 51, 2916
Jones, R. E. (1966). Studies on the proteolytic enzymes of the foetal yolk sac of the rabbit. M.Sc. Thesis, University of Wales
Jones, R. E. (1974). Studies in vivo and in vitro of the transfer of rat IgG and rat albumen across the intestinal walls of young rats. Biol. Neonat, 24, 220
Jones, R. E. (1976). Studies on the transmission of bovine IgG across the intestine of the young rat. In: (W. A. Hemmings (ed.), Maternofoetal Transmission of Immunoglobulins p.325–337. (London: Cambridge University Press)
Mackenzie, D. D. S. (1972). Selective uptake of immunoglobulin by the proximal intestine of suckling rats. Am. J. Physiol., 223, 1286
Morris, B. and Morris, R. (1976). Quantitative assessment of the transmission of labelled protein by the proximal and distal regions of the small intestine of young rats. J. Physiol., 255, 619
Morris, I. G. (1963). Interference with the uptake of guinea-pig agglutinins in mice due to fractions of papain hydrolysed rabbit gamma-globulin. Proc. R. Soc. B, 157, 160
Morris, I. G. (1964). The transmission of antibodies and normal gamma-globulins across the young mouse gut. Proc. R. Soc. B, 160, 276
Morris, I. G. (1974). Immunological proteins. In: (D. H. Smyth (ed), Intestinal Absorption p.483–540. (London: Plenum Press.)
Porter, P.P. (1959). The hydrolysis of rabbit gamma-globulin and antibodies with crystalline papain. Biochem. J., 73, 119
Rodewald, R. (1970). Selective antibody transport in the proximal small intestine of the neonatal rat. J. Cell Biol., 45, 635
Rodewald, R. (1973). Intestinal transport of antibodies in the newborn rat. J. Cell Biol., 58, 189
Rodewald, R. (1976). Intestinal transport of peroxidase-conjugated IgG fragments in the neonatal rat. In: (W. A. Hemmings (ed.), Maternofoetal Transmission of Immunoglobulins p. 137–149. (London: Cambridge University Press)
Schlamowitz, M. (1976). Maternofoetal transmission of protein in the rabbit: transfer in vivo and binding in vitro to the yolksac membrane. In: (W. A. Hemmings (ed.), Maternofoetal Transmission of Immunoglobulins p. 179–199. (London: University Press)
Vacek, Z. (1964). Submikroskopická a cytochemie epithelu tenkého strevg. u krysich mlád’at. Cslká Morf., 12, 292
Waldmann, T. A. and Jones, E. A. (1976). The role of IgG-specific cell surface receptors in IgG transport and catabolism. In: (W. A. Hemmings (ed.), Maternofoetal Transmission of Immunoglobulins p.123–133. (London: Cambridge University Press)
Weissmann, G. (1968). The effects of steroids and drugs on lysosomes. In: (J. T. Dingle and Honor B. Fell, (ed.), Lysosomes in Biology and Pathology p.276–295. (Amsterdam: North Holland)
Wild, A. E. (1974). Protein transport across the placenta. Symp. Soc. Exp. Biol., 28, 521
Wild, A. E. (1976). Mechanism of protein transport across the rabbit yolk sac endoderm. In: (W. A. Hemmings (ed.), Maternofoetal Transmission of Immunoglobulins p.155–165. (London: University Press)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 MTP Press Limited
About this chapter
Cite this chapter
Morris, I.G. (1978). The receptor hypothesis of protein ingestion. In: Hemmings, W.A. (eds) Antigen Absorption by the Gut. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6609-6_2
Download citation
DOI: https://doi.org/10.1007/978-94-011-6609-6_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6611-9
Online ISBN: 978-94-011-6609-6
eBook Packages: Springer Book Archive