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Structure, Function and Evolution of the 3′ Ends of Small Ribosomal Subunit RNA

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Summary

During the last few years we have studied the structure and the function of a stem-loop structure in the RNA of small ribosomal subunits. This part of the RNA is extremely conserved containing almost without exception the same number of base-pairs and no mismatches or bulged nucleotides. The loop con-sists of either (m2)GGm 62 Am 62 A (bacteria and organelles) or UGm 62 Am 62 A (cytoplasm). Experimentally it was shown that structural and thermodynamic properties are related to the presence of conserved features. Functionally, alterations in this region (e. g. removal of methyl groups) exert pleiotropic effects on initiation and elongation of protein synthesis, and on subunit interaction. Evidence will be presented that the methyl groups play a role in ribosomal fidelity.

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Authors and Affiliations

  1. State University of Leiden, Leiden, The Netherlands

    P. H. van Knippenberg, H. A. Heus & C. P. J. J. van Buul

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  1. P. H. van Knippenberg
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  2. H. A. Heus
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  3. C. P. J. J. van Buul
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Robert E. Glass Jaroslav Spižek

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© 1985 Robert E. Glass and Jaroslav Spižek

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van Knippenberg, P.H., Heus, H.A., van Buul, C.P.J.J. (1985). Structure, Function and Evolution of the 3′ Ends of Small Ribosomal Subunit RNA. In: Glass, R.E., Spižek, J. (eds) Gene Manipulation and Expression. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6565-5_34

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  • DOI: https://doi.org/10.1007/978-94-011-6565-5_34

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6567-9

  • Online ISBN: 978-94-011-6565-5

  • eBook Packages: Springer Book Archive

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