Effect of Pharmacological Agents on Normalization of Molecular and Histologic Dysfunction Following Traumatic Injury to the Spinal Cord
Despite impressive achievements in the rehabilitation of spinal cord injured subjects, the following important areas of research have not been adequately investigated: (1) the general underlying pathophysiologic problems that occur in traumatically paralyzed subjects who undergo osteoporosis, periarticular bone formation, episodic hypertensive crises, and so forth; (2) mitigation of serious dysfunction by vigorous pharmacologic or surgical intervention to preserve as much sensory and motor function as possible, or both; and (3) the possibility of the elimination of paralysis per se.
KeywordsSpinal Cord Spinal Cord Injury Tyrosine Hydroxylase Biogenic Amine Spinal Cord Segment
Unable to display preview. Download preview PDF.
- Cajal, S., and Ramon, Y. Degeneration and Regeneration of the Nervous System, Hafner, New York (1928).Google Scholar
- Flamm, E.W., Viau, A.T., Ransohoff, J., and Naftchi, N.E., Neurology 26: 664–666. Google Scholar
- Levitt, M., Spector, S., Sjoerdsma, A., and Udenfriend, S., J. Pharm. Exper. Therap. 148: 1–8 (1965).Google Scholar
- Molinoff, P.B., Weinshilboum, R., and Axelrod, J., J. Pharmacol. Exp. Therap. 178: 425–431 (1971).Google Scholar
- Naftchi, N.E., Demeny, M., Lowman, E.W., and Tuckman, J., Circ. 57 (No. 2): 336–341 (1978).Google Scholar
- Naftchi, N.E., Demeny, M., Flamm, E.S., and Lowman, E.W., Catecholamines and Stress, Pergamon Press, Great Britain, p. 367–375 (1976).Google Scholar
- Rothman, J.E., and Engelman, D.M., Nature 237: 24–44 (1972).Google Scholar
- Wurtman, R.J., Chou, C., and Rose, C. J., Pharmacol. Exp. Therap. 174: 351–356 (1970).Google Scholar