Abstract
The questions of why sleep is required by higher animals, and of what instigates sleep, are hardly novel. Though the answers must ultimately be couched largely in chemical terms, biochemical studies of sleep are not very numerous. Recently, however, the tempo of research has quickened and two reviews have appeared within the past three years that offer a glimpse both of the more historical aspects of the field and of recent progress (Guiditta, 1977; Karnovsky and Reich, 1977). Though these reviews were written completely independently of each other, by authors with entirely different fundamental interests, they cover virtually the same ground, and even offer several identical examples from the literature. This one might take as an indication of how small is the number of biochemical laboratories that are engaged in research on sleep.
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References
Anchors, J.M., Haggerty, D.F., and Karnovsky, M.L. Cerebral glucose-6-phosphatase and the movement of 2-deoxy-D-glucose across cell membranes. J. Biol. Chern. 252, 7035–7041 (1977).
Anchors, J.M., and Karnovsky, M.L. Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep. J. Biol. Chem. 250, 6408–6416 (1975).
Arion, WJ., Wallin, B.K., Carlson, P.W., and Lange, AJ. The Specificity of glucose-6-phosphatase of intact liver microsomes. J. Biol. Chem. 247, 2558–2565 (1972).
Cabantchik, Z.I., Knauf, P.A., and Rothstein, A. The anion transport system of the red blood cell: The role of membrane protein evaluated by the use of probes. Biochem. Biophys. Acta 515, 239–302 (1978).
Cocks, J.A. Change in the concentration of lactic acid in the rat and hamster brain during natural sleep. Nature 215, 1399–1400 (1967).
Cohen, H.B., and Dement, W.C. Sleep: changes in threshold to electroconvulsive shock in rats after deprivation of “paradoxical phase.” Science 150, 1318–1319 (1965).
Feldman, F., and Butler, L.G. Protein bound phosphoryl histidine: A probable intermediate in the microsomal glucose-6-phosphatase/inorganic pyrophosphatase reaction. Biochem. Biophys. Acta 268, 698–710 (1972).
Fencl, V., Koski, G., and Pappenheimer, J.R. Factors in cerebrospinal fluid from goats that affect sleep and activity in rats. J. Physiol. 216, 565–589 (1971).
Giuditta, A. The biochemistry of sleep, in Biochemical Correlates of Brain Structure and Function. A.N. Davison, ed. Academic Press, London (1977), pp. 293–337.
Hawkins, R.A., and Miller, A.L. Loss of radioactive 2-deoxy-D-glucose-6-phosphate from brains of conscious rats: Implications for quantitative auto radiographic determination of regional glucose utilization. Neuroscience 3, 251–258 (1978).
Jouvet, M. The role of monoamines and acetyl-choline-containing neurones in the regulation of the sleep-waking cycle. Ergeb. Physiol. 64, 166–307 (1972).
Jouvet, D., Vimont, P., Delorme, F., and Jouvet, M. Etude de la privation selective de la phase paradoxale de sommeil chez le chat. C. R. Soc. Biol. (Paris) 158, 456–759 (1964).
Karadzik, V., and Mrsulja, B. Deprivation of paradoxical sleep and brain glycogen. J. Neurochem. 16,29–34 (1969).
Karnovsky, M.L., and Reich, P. Biochemistry of sleep, in Advances in Neurochemistry. B.W. Agranoff and M.H. Aprison, eds. Plenum Press, New York (1977), Vol. 2, pp. 213–275.
Katz, J., and Rognstad, R. Futile cycles in the metabolism of glucose, in Current Topics in Cellular Regulation. B.L. Horecker and E.R. Stadtman, eds. Academic Press, New York (1976), Vol. 10, pp. 237–289.
Kennedy, e., Des Rosiers, M.H., Jehle, J.W., Reivich, M., Sharpe, F., and Sokoloff, L. Mapping of functional neuronal pathways by autoradiographic survey of local metabolic rate with 14C-deoxyglucose. Science 187, 850–853 (1975).
Krueger, J.M., Pappenheimer, J.R., and Karnovsky, M.L. Sleep-promoting factors: purification and properties. Proc. Nat. Acad. Sci. 75, 5235–5238 (1978).
Legendre, R., and Pieron, H. Des resultats histo-physiologiques de l’injection intra-occipito atlantodienne des liquide insomniques. C. R. Soc. Biol. (Paris) 68, 1108–1109 (1910).
Legendre, R., and Pieron, H. Recherches sur le besoin de sommeil couse cutif a une veille prolongee. Z. AUg. Physiol. 14,235–262 (1913).
Mendelson, W., Guthrie, R.D., Guynn, R., Harris, R.L., and Wyatt, RJ. Rapid eye movement (REM) sleep deprivation, stress, and intermediary metabolism. J. Neurochem. 22, 1157–1159 (1974).
Monnier, M., Hatt, A.M., Cueni, L.B., and Schoenenberger, R.A. Humoral transmission of sleep VI. Purification and assessment of a hypnogenic fraction of “sleep dialysate” (factor delta). Pjlugers Arch. 331, 257–265 (1972).
Monnier, M., and Hosli, L. Dialysis of sleep and waking factors in blood of the rabbit. Science 146, 796–798 (1964).
Monnier, M., and Schoenenberger, G.A. Erzeugung, Isolierung und Charakterisierung eines physiologische Schlaffaktors “Delta.” Schweiz. Med. Wochenschr. 103, 1733–1743 (1973).
Nagasaki, H., Iriki, M., Inoue, S., and Uchizono, K. The presence of a sleep-promoting material in the brain of sleep-deprived rats. Froc. Japan. A cad. 50, 241–246 (1974).
Newsholme, E., and Crabtree, B.: Substrate cycles in the control of energy metabolism in the intact animal, in Symposium Al Regulatory Mechanisms of Carbohydrate Metabolism. V. Esmann, ed. Federation of European Biochemical Societies, II th meeting, Copenhagen, Pergamon Press, New York (1978), Vol. 42, pp. 285–295.
Nilsson, O.S., Arion, W.J., DePierre, J.W., Dallner, G., and Ernster, L. Evidence for the involvement of a glucose-6-phosphate carrier in microsomal glucose-6-phosphatase activity. Eur. J. Biochem. 82, 627–638 (1978).
Nordlie, R.C. Glucose-6-phosphatase, hydrolytic and synthetic activities, in The Enzymes P.O. Boyer, ed. Academic Press, New York (1971), Vol. 4, pp. 543–605.
Nordlie, R.C. Metabolic regulation by multifunctional glucose-6-phosphatase, in Current Topics in Cellular Regulation. B.L. Horecker and E.R. Stadtman, eds. Academic Press, New York (1974), Vol. 8, pp. 33–117.
Pappenheimer, J.R., Koski, G., Fencl, V., Karnovsky, M.L., and Krueger, J. Extraction of sleep-promoting Factor S. from cerebrospinal fluid and from brains of sleep-deprived animals. J. Neurophysiol. 38, 1299–1311 (1975).
Passonneau, J.V., and Lauderdale, V.R. A comparison of three methods of glycogen measurement in tissues. Anal. Biochem. 60, 405–412 (1974).
Pieron, H. Le probleme physiologique du sommeil. Masson, Paris (1913).
Reich, P., Driver, J.K., and Karnovsky, M.L. Sleep: effects on incorporation of inorganic phosphate into brain fractions. Science 157, 336–338 (1967).
Reich, P., Geyer, S.J., and Karnovsky, M.L. Metabolism of brain during sleep and wakefulness. J. Neurochem. 19, 487–497 (1972).
Reich, P., Geyer, S.J., Steinbaum, L., Anchors, J.M., and Karnovsky, M.L. Incorporation of phosphate into rat brain during sleep and wakefulness. J. Neurochem. 20, 1195–1205 (1973).
Reivich, M., Isaacs, G., Evarts, E., and Kety, S.S. The effect of slow-wave sleep and REM sleep on regional cerebral blood flow in cats. J. Neurochem. 15, 301–306 (1968).
Richter, D., and Dawson, R.M.C. Brain metabolism in emotional excitement and in sleep. Am. J. Physiol. 154, 73–79 (1948).
Roldan, E., and Weiss, T. Neural mechanisms underlying sleep cycle in rodents. Bol. Inst. Estud. Med. Biol. Mex. 24, 467–483 (1963).
Schnedorf, J.G., and Ivy, A.C. An examination of the hypnotoxin theory of sleep. Am. J. Physiol. 125, 491–505 (1939).
Schoenenberger, G.A., Maier, P.F., Tobler, H.J., Wilson, K., and Monnier, M. The delta EEG (sleep)-inducing peptide (DSIP) XI. Amino acid analysis, sequence, synthesis and activity of the nonapeptide. Pflugers Arch. 376, 119–129 (1978).
Shimizu, H., Tabushi, K., Hishikawa, Y., Kakimoto, Y., and Kaneko, Z. Concentrations of lactic acid in rat brain during natural sleep. Nature 212,936–937 (1966).
Sokoloff, L., Reivich, M., Kennedy, C., Des Rosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakuroda, O., and Shinohara, M. The 14C-deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28,897–916 (1977).
Stephens, H.R., and Sandborn, E.B. Cytochemical localization of glucose-6-phosphatase activity in the central nervous system of the rat. Brain Res. 113, 127–146 (1976).
Steriade, M., and Hobson, J.A. Neuronal activity during the sleep-waking cycle. Prog. Neurobiol. 6, 155–376 (1976).
Van den Noort, S., and Brine, K. Effect of sleep on brain labile phosphates and metabolic rate. Am. J. Physiol. 218, 1434–1439 (1970).
Veech, R.L., and Hawkins, R.A. Brain blowing: a technique for in vivo study of brain metabolism, in Research Methods in Neurochemistry. N. Marks and R. Rodnight, eds. Plenum Press, New York-London (1974), Vol. 2, pp. 171–182.
Zakim, D., and Vessy, P.A. Techniques for the characterization of UDP-glucuronyltransferase, glucose-6-phosphate, and other tightly bound microsomal enzymes, in Methods in Biochemical Analysis. D. Glick, ed. John Wiley and Sons, New York (1973), Vol. 21, pp. 1–37.
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Karnovsky, M.L. (1982). Biochemical Factors Associated with the Sleep State. In: Beckman, A.L. (eds) The Neural Basis of Behavior. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6302-6_3
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DOI: https://doi.org/10.1007/978-94-011-6302-6_3
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