Abstract
Recently the isolated normothermically perfused rat kidney has been used as a test system of kidney preservation1–3. Kidneys flushed with hypertonic citrate solution before ice-storage functioned better than others flushed with Collins’, Sacks’ or Perfudex solutions1. The citrate flushing solution required both citrate and magnesium for efficacy but tricarballyate, a non-metabolizable analogue, could replace citrate if suitably buffered3. Hyper-osmolality did not enhance the efficacy of the solution; an isosmolar solution was more effective3. Subsequent studies have shown that replacing part or all of the mannitol with glucose further enhanced the efficacy of the isosmolar citrate solution.
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References
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© 1982 MTP Press Limited
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Marshall, V., Jablonski, P., Howden, B., Leslie, E., Rae, D., Scott, D.F. (1982). Cold storage and machine preservation of kidney: studies with the isolated rat kidney. In: Pegg, D.E., Jacobsen, I.A., Halasz, N.A. (eds) Organ Preservation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6267-8_31
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DOI: https://doi.org/10.1007/978-94-011-6267-8_31
Publisher Name: Springer, Dordrecht
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