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Biological significance and therapeutic potential of prostacyclin

  • S. Moncada
  • J. R. Vane

Abstract

Prostacyclin and thromboxane A2 (TXA2) are both derived from arachidonic acid, a fatty acid present in the phospholipids of cell membranes. TXA2 is an unstable (t1/2 30s at 37 °C), powerful vasoconstrictor agent generated by platelets1. Prostacyclin is also unstable (t1/2 3 min at 37 °C) but induces vasodilatation and inhibits platelet aggregation. Prostacyclin and thromboxane A2 represent, therefore, the opposite poles of a homeostatic mechanism for regulation of platelet aggregability in vivo. Manipulation of this control mechanism will affect thrombus and haemostatic plug formation.

Keywords

Peripheral Artery Disease Inhibit Platelet Aggregation Prostaglandin Endoperoxide Prostacyclin Production Arteriosclerosis Obliterans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • S. Moncada
  • J. R. Vane

There are no affiliations available

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