Deuterium oxide (D2O) for organ preservation

  • J. H. Fischer
  • G. Reifferscheidt
  • M. Fuhs
  • M. Wenzel
  • W. Isselhard


Organ preservation nowadays is limited by the development of cellular damage which is mainly damage to cellular membranes. The course of damage can be slowed down by oxygenated preservation, i. e. continuous perfusion or retrograde oxygen persufflation, but it cannot be prevented. Many efforts have been made to reduce the damaging effects by use of special flush solutions which reduce oedema formation and electrolyte redistribution but a real protection of membranes has not yet been achieved.


Adenine Nucleotide Total Body Water Oedema Formation Organ Preservation Deuterium Oxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Wenzel, M. and Lemm, U. (1980). Stabilization of enzymes and antisera in heavy water (D20). J. Clin. Chem. Clin. Biochem., 18, 684Google Scholar
  2. 2.
    Wenzel, M. (1976). Schutzeffekt von Schwerem Wasser (D20) bei der Schädigung von Human-Erythrocyten durch thermische und osmotische Einflüsse. J. Clin. Chem. Clin. Biochem., 14, 185PubMedGoogle Scholar
  3. 3.
    Fischer, J.H., Asmuth, C. and Wenzel, M. (1981). Asphyxie-Schutz durch Schweres Wasser (D20). Experientia, 37, 263PubMedCrossRefGoogle Scholar
  4. 4.
    Fischer, J.H., Kulus, D., Hansen-Schmidt, I. and Isselhard, W. (1981). Adenine nucleotide levels of canine kidneys during hypothermic aerobic or anaerobic storage in Collins’ solution. Eur. Surg. Res., 13, 181CrossRefGoogle Scholar
  5. 5.
    Lambotte, L. and Wojcik, S. (1978). Measurement of cellular oedema in anoxia and its prevention by hyperosmolar solutions. Surgery, 83, 94PubMedGoogle Scholar
  6. 6.
    Bretschneider, H.J. (1980). Myocardial protection. Thorac. Cardiovasc. Surg., 28, 295PubMedCrossRefGoogle Scholar
  7. 7.
    Collins, G. M., Bravo-Shugarman, M. and Terasaki, P.J. (1969). Kidney preservation for transportation. Lancet, 2, 1219PubMedCrossRefGoogle Scholar
  8. 8.
    Miyata, M., Fischer, J.H., Fuhs, M., Isselhard, W. and Kasai, Y. (1980). A simple method for orthotopic liver transplantation in the rat. Transplantation, 30, 335PubMedCrossRefGoogle Scholar
  9. 9.
    Thompson, J.F. (1963). Biological Effects of Deuterium. ( Oxford: Pergamon Press )Google Scholar

Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • J. H. Fischer
  • G. Reifferscheidt
  • M. Fuhs
  • M. Wenzel
  • W. Isselhard

There are no affiliations available

Personalised recommendations