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Flush preservation

  • Chapter
Organ Preservation

Abstract

Tolerance of the kidney to normothermic ischaemia would appear to be in the range of 1–2h1,2. In general, it has been found that the protection afforded by simple cooling is related to the reduction in temperature3, the maximum preservation time by ice immersion being in the range of 12–24h4,5. This period, however, falls short of that theoretically attainable considering the degree of metabolic suppression produced by cooling to 0°C6,7. This relative failure of ice immersion to reach its full theoretical potential may be explained by two considerations. First, surface cooling is an inefficient method for reducing the core temperature of a large organ8. The detrimental effects of even a short period of normothermic ischaemia on kidneys subsequently preserved by simple hypothermia is well recognized9,10. Secondly, cooling itself has an adverse effect on cell physiology which can be minimized by the use of appropriate flush solutions.

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  1. G. M. Collins
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Editors and Affiliations

  1. MRC Medical Cryobiology Group, University Department of Surgery, Douglas House,Trumpington Road, CB2 2AH, Cambridge, UK

    D. E. Pegg

  2. Department of Nephrology, University Hospital, DK-5000, Odense C, Denmark

    I. A. Jacobsen

  3. Department of Surgery, University of California Medical Center, 225 Dickinson Street, 92103, San Diego, California, USA

    N. A. Halasz

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Collins, G.M. (1982). Flush preservation. In: Pegg, D.E., Jacobsen, I.A., Halasz, N.A. (eds) Organ Preservation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6267-8_22

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  • DOI: https://doi.org/10.1007/978-94-011-6267-8_22

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