Effect of chlorpromazine on the contractile function and metabolic status of continuously perfused and ischaemic hearts

  • G. E. Thomas
  • S. Levitsky
  • H. Feinberg


Cardiac surgical procedures that require a period of ischaemia, e. g. coronary bypass, entail a significant risk of myocardial damage. Reperfusion of ischaemic myocardium may aggravate ischaemic damage by inducing a further drop in ATP, a rise in diastolic pressure and a loss of compliance. In part, the compliance loss has been attributed to Ca2+ accumulation during reperfusion, particularly into mitochondria1. Recently pretreatment (30min before sacrifice) of rats with chlorpromazine (CPZ) (30mg/kg, i. p.) was shown to reverse the loss of liver mitochondrial function seen after 3h of ischaemia2. In particular the 4-fold increase in mitochondrial Ca2+, seen after reperfusion in the untreated animals, did not occur in the CPZ-treated rats.


Coronary Flow Continuous Perfusion Ischaemic Damage Ischaemic Myocardium Balloon Volume 
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  1. 1.
    Shen, A.C. and Jennings, R.B. (1972). Kinetics of calcium accumulation in acute myocardial ischemic injury. Am. J. Pathol., l67, 441PubMedGoogle Scholar
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    Mittnacht, S. Jr, Sherman, S.C. and Farber, J.C. (1979). Reversal of ischemic mito-chondrial dysfunction. J. Biol. Chem., 254, 9871PubMedGoogle Scholar
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    Holland, C.E., Feinberg, H., Levitsky, S., Buinevicius, Z. and Wright, R.N. (1978). Serial myocardial biopsies using an improved microfluorometric assay. J. Surg. Res., 25, 342PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • G. E. Thomas
  • S. Levitsky
  • H. Feinberg

There are no affiliations available

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