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Effect of chlorpromazine on the contractile function and metabolic status of continuously perfused and ischaemic hearts

  • G. E. Thomas
  • S. Levitsky
  • H. Feinberg

Abstract

Cardiac surgical procedures that require a period of ischaemia, e. g. coronary bypass, entail a significant risk of myocardial damage. Reperfusion of ischaemic myocardium may aggravate ischaemic damage by inducing a further drop in ATP, a rise in diastolic pressure and a loss of compliance. In part, the compliance loss has been attributed to Ca2+ accumulation during reperfusion, particularly into mitochondria1. Recently pretreatment (30min before sacrifice) of rats with chlorpromazine (CPZ) (30mg/kg, i. p.) was shown to reverse the loss of liver mitochondrial function seen after 3h of ischaemia2. In particular the 4-fold increase in mitochondrial Ca2+, seen after reperfusion in the untreated animals, did not occur in the CPZ-treated rats.

Keywords

Coronary Flow Continuous Perfusion Ischaemic Damage Ischaemic Myocardium Balloon Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Shen, A.C. and Jennings, R.B. (1972). Kinetics of calcium accumulation in acute myocardial ischemic injury. Am. J. Pathol., l67, 441PubMedGoogle Scholar
  2. 2.
    Mittnacht, S. Jr, Sherman, S.C. and Farber, J.C. (1979). Reversal of ischemic mito-chondrial dysfunction. J. Biol. Chem., 254, 9871PubMedGoogle Scholar
  3. 3.
    Holland, C.E., Feinberg, H., Levitsky, S., Buinevicius, Z. and Wright, R.N. (1978). Serial myocardial biopsies using an improved microfluorometric assay. J. Surg. Res., 25, 342PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • G. E. Thomas
  • S. Levitsky
  • H. Feinberg

There are no affiliations available

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