Effect of chlorpromazine on the contractile function and metabolic status of continuously perfused and ischaemic hearts
Cardiac surgical procedures that require a period of ischaemia, e. g. coronary bypass, entail a significant risk of myocardial damage. Reperfusion of ischaemic myocardium may aggravate ischaemic damage by inducing a further drop in ATP, a rise in diastolic pressure and a loss of compliance. In part, the compliance loss has been attributed to Ca2+ accumulation during reperfusion, particularly into mitochondria1. Recently pretreatment (30min before sacrifice) of rats with chlorpromazine (CPZ) (30mg/kg, i. p.) was shown to reverse the loss of liver mitochondrial function seen after 3h of ischaemia2. In particular the 4-fold increase in mitochondrial Ca2+, seen after reperfusion in the untreated animals, did not occur in the CPZ-treated rats.
KeywordsCoronary Flow Continuous Perfusion Ischaemic Damage Ischaemic Myocardium Balloon Volume
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