Dependence Liability of Benzodiazepines in Humans

  • John Marks


An attempt has been made to determine the dependence liability that exists in practice in the case of the benzodiazepines. The existence of such a dependence liability and the extent of the dependence risk has been assessed in four ways:
  1. 1.

    Deliberate experiments in humans to provoke physical dependence.

  2. 2.

    Ex cathedra statements from those working directly in the field of drug abuse.

  3. 3.

    A critical analysis of the published reports of psychological and physical dependence arising in either an abuse or a therapeutic situation.

  4. 4.

    Large-scale surveys of groups of patients.



Physical Dependence Withdrawal Reaction Dependence Risk Multiple Drug Abuse Psychological Dependence 
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Copyright information

© John Marks 1978

Authors and Affiliations

  • John Marks
    • 1
  1. 1.Medical StudiesGirton CollegeCambridgeUK

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