Abstract
Two hundred years ago Cotunnius1 associated oedema with coagulable substances in the urine. These observations were brilliantly extended by Richard Bright 50 years later2 who, in collaboration with his chemist Dr Bostock, demonstrated a disturbance in excretion of urea associated with a full pulse, oedema, albuminous urine and contracted kidneys. One year later, in 1828, Wohler was the first to synthesize urea from inorganic radicles and wrote to Berzelius: ‘I must tell you that I can prepare urea without requiring a kidney or an animal, either man or dog’3.
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Parsons, F.M. (1978). Introduction. In: Anderton, J.L., Parsons, F.M., Jones, D.E. (eds) Living with renal failure. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6185-5_1
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DOI: https://doi.org/10.1007/978-94-011-6185-5_1
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