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Transfer Factor: Clinical Usage and Experimental Studies

  • A. Basten
  • S. Croft

Abstract

Transfer factor (TF) is defined as a dialysable cell-free leukocyte extract with the capacity to transfer delayed-type hypersensitivity (DTH) from an immune to a non-immune individual in a specific manner. It was originally described by Lawrence1,2 in a classical series of experiments in which DTH to the PPD and streptococcal M substance was transferred to naive recipients as judged by conversion of skin test reactivity. Despite the potential value of TF as a therapeutic tool, Lawrence’s observations were regarded with scepticism or ignored for many years. It was not until 1970 that TF was first used in treatment of human disease3. Since then it has been given with various degrees of success to patients with a wide range of immunological problems including immunodeficiency states, recurrent or disseminated infections and malignancy. This has resulted in intense interest in its properties and mode of action, in accumulation of a substantial literature and in the holding of two international workshops (1973, 1976).

Keywords

Skin Test Migration Inhibition Factor Transfer Factor Clinical Usage Lymphocyte Transformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1978

Authors and Affiliations

  • A. Basten
    • 1
  • S. Croft
    • 1
  1. 1.Immunology Unit, Department of BacteriologyThe University of SydneyAustralia

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