Abstract
There have been reports1, 2 on the increased risk of both arterial and venous thrombosis in patients taking combined estrogen/progestogen oral contraceptives, and the synthetic estrogen has been particularly implicated3. Other workers have noted differences in behaviour between natural and synthetic estrogens4.
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References
Collaborative Study (1973). Oral contraception and increased risk of cerebral ischemia or thrombosis. New Eng. J. Med., 288, 871
Inman, W. H. W. and Vessey, M. P. (1968). Investigations of deaths from pulmonary, coronary and cerebral thrombosis and embolism in women of child-bearing age. Brit. Med. J., ii, 193
Inman, W. H. W., Vessey, M. P., Westerholm, B. and Engelund, A. (1970). Thromboembolic disease and the steroidal content of oral contraceptives. A report to the Committee on Safety of Drugs. Brit. Med. J., ii, 203
Elkeles, R. S., Hampton, J. R. and Mitchell, J. R. A. (1968). Effect of oestrogens on human platelet behaviour. Lancet, ii, 315.
Kanncl, W. B., Castelli, W. P., Gordon, T. and McNamara, P. M. (1971). Serum cholesterol, lipoproteins and the risk of coronary heart disease: The Framingham Study. Ann. Intern. Med., 74, 1
Carlson, L. A. and Bottinger, L. E. (1972). Ischaemic heart disease in relation to fasting values of plasma triglycerides and cholesterol. Lancet, i, 865
Robertson, G. and Cramp, D. G. (1970). An evaluation of cholesterol determinations in serum and serum lipoprotein fractions by a semi-automated fluorimetric method. J. Clin. Pathol., 23, 243
Kessler, G. and Lederer, H. (1966). Fluorimetric measurements of triglycerides. Automation in Analytical Chemistry (Editor: L. T. Skeggs) p. 341 (New York: Mediad Inc.)
Noble, R. P. (1968). Electrophoretic separation of plasma lipoproteins in agarose gel. J. Lipid Res., 9, 693
Fearnley, G. R. and Tweed, J. M. (1953). Evidence of an active fibrinolytic enzyme in the plasma of normal people with observations of inhibition associated with the presence of calcium. Clin. Sci., 12, 81
Fearnley, G. R. and Chakrabarti, R. (1966). Fibrinolytic treatment of rheumatoid arthritis with phenformin plus ethyloestrenol. Lancet, ii, 757
Borchgrevinck, C. (1960). A method for measuring platelet adhesiveness in vivo. Acta Med. Scand., 168, 157
Eastham, R. D. (1962). An improved plasma recalcified clotting test and its modification as a simple rapid heparin retarded clotting test. J. Clin. Pathol., 15, 86
Wynn, V., Doar, J. W. H., Mills, G. L. and Stokes, T. (1969). Fasting serum triglyceride, cholesterol and lipoprotein levels during oral contraceptive therapy. Lancet, ii, 756
Stokes, T. and Wynn, V. (1971). Serum lipids in women on oral contraceptives. Lancet, ii, 677
Snadjerman, M. and Oliver, M. F. (1963). Spontaneous premature menopause, ischaemic heart disease and serum lipids. Lancet, i, 962
Aitken, J. M., Lorimer, A. R., McKay Hart, D., Lawrie, T. D. V. and Smith, D. A. (1971). The effects of oophorectomy and long-term Mestranol therapy on the serum lipids of middle-aged women. Clin. Sci., 41, 597
Stamler, J., Pick, R., Katz, L. N., Pick, A., Kaplan, B. M., Berkson, D. M. and Century, D. (1963). The effectiveness of estrogen therapy on myocardial infarction in middle-aged men. J. Amer. Med. Assoc., 183, 632
Marmorsten, J., Moore, F. J., Hopkins, C. E., Kuzma, O. T. and Werner, J. (1962). Clinical studies of long-term estrogen therapy in men with myocardial infarction. Proc. Soc. Exp. Biol. Med., 110, 400
Robinson, R. W. and LeBeau, R.J. (1965). Effect of conjugated equine estrogens on serum lipids and the clotting mechanism. J. Atheroscl. Res., 5, 120
Furman, R. H., Alaupovic, P. and Howard, R. P: (1967). Effect of androgens and estrogens on serum lipids and the composition and concentrations of serum lipoproteins in normolipemic and hyperlipidemic states. Prog. Biochem. Pharmacol., 2, 215
Utian, W. H. (1970). Cholesterol, coronary heart disease and estrogens. Ph.D. Thesis, University of Cape Town
Boyd, G. S. (1963). Hormones and cholesterol metabolism. Biochem. Soc. Symp., 24. 79
Leading Article (1972). Blood clotting and the Pill. Brit. Med. J., iv, 378
Bolton, C. H., Hampton, J. R. and Mitchell, J. R. A. (1968). Effect of oral contraceptive agents on platelets and plasma phospholipids. Lancet, i, 1336
Coope, J., Thompson, J. M. and Poller, L. (1975). Effects of ‘natural oestrogen’ replacement therapy on menopausal symptoms and blood clotting. Brit. Med. J., iv, 139
Israel, S. L. (1967). In: Diagnosis and Treatment of Menstrual Disorders and Sterility, 5th Edn. p. 41. (New York: Hoeber Medical Division, Harper and Row)
Yannone, M. E. (1967). The use of hormones in the menopause. J. Iowa Med. Soc., 57, 1099
Kistner, R. W. (1967). Feminine for ever? An evaluation of therapy during the peri-menopause. Med. Sci., 18, 42
Rudel, H. W. and Kincl, F. A. (1966). The biology of anti-fertility steroids. Acta Endocrinol., 51, Suppl. 105
Schalch, D. S., Parlow, A. F., Boon, R. C., Reichlin, S. and Lee, L. A. (1968). Measurement of human luteinising hormone in plasma by radioimmunoassay. J. Clin. Invest., 47, 665
Wise, A. J., Gross, M. A. and Schalch, D. S. (1973). Quantitative relationships of the pituitary-gonadal axis in post-menopausal women. J. Lab. Clin. Med., 81, 28
Hazzard, W. R., Spiger, M. J., Bagdade, J. P. and Bierman, E. L. (1969). Studies on the mechanism of increased plasma triglyceride levels induced by oral contraceptives. New Eng. J. Med., 280, 471
Adams, J. H., Mitchell, J. R. A. and Soppitt, G. D. (1970). Effect of oral contraceptives on lipoprotein lipase activity and platelet stickiness. Lancet, ii, 333
Rössner, S., Larsson-Cohn, U., Carlson, L. A. and Boberg, J. (1971). Effects of an oral contraceptive agent on plasma lipids, plasma lipoproteins, the intravenous fat tolerance and post-heparin lipolytic activity. Acta Med. Scand., 190, 301
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Bolton, C.H. (1976). The effects of ethinyl estradiol and conjugated equine estrogens on plasma lipids in oophorectomized women. In: Campbell, S. (eds) The Management of the Menopause & Post-Menopausal Years. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6165-7_16
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DOI: https://doi.org/10.1007/978-94-011-6165-7_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-6167-1
Online ISBN: 978-94-011-6165-7
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