Enteric infection and immunization

  • Robert L. Clancy
  • John Bienenstock


The principles of oral immunization were recognized more than 50 years ago, when Besredka1 described a state of immunity following oral vaccines unrelated to circulating antibody, leading him to conclude that ‘the plan in artificial vaccination, therefore, is to follow the route which the virus takes in its penetration into the body’. Detection of faecal antibody prior to its appearance in the circulation following human bacillary dysentery by Davies2 in 1922, and the correlation of resistance to experimental cholera infection of guinea pigs with coproantibody by Burrows3 in 1950, are representative of the early studies which supported Besredka’s postulates. Identification of IgA as a more specific marker of a ‘secretory immunoglobulin system’ by Tomasi et al.4 in 1965 stimulated a renewed interest in the local immune response and provided impetus to reopen the search for local vaccines to enhance mucosal resistance. The structure and function of secretory IgA has been extensively reviewed5−12 independently, and in the context of local immunity.


Typhoid Fever Enteric Infection Oral Vaccination Enterovirus Infection Immunological Aspect 
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Copyright information

© MTP Press Ltd. 1976

Authors and Affiliations

  • Robert L. Clancy
  • John Bienenstock

There are no affiliations available

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