Experimental Studies on the Prevention of Rh Haemolytic Disease
In the context of haemolytic disease of the newborn, ABO incompatibility means that the father’s blood is unsuitable for transfusion into the mother, and our interest in this stems from the work of Levine (1943), who noted a deficiency of such mating types in the parents of affected children. He deduced, therefore, that ABO incompatibility affords a degree of protection against Rh haemolytic disease, and this has been confirmed by many workers. Of particular interest are the experiments of Stern et al. (1956), who showed that male volunteers could be much more easily sensitized to Rh if the injected blood were ABO compatible.
KeywordsFoetal Cell Foetal Blood Maternal Circulation Placental Barrier Haemolytic Disease
Unable to display preview. Download preview PDF.
- Clarke, C. A., Finn, R., McConnell, R. B., and Sheppard, P. M. (1958). Int. Arch. Allergy, 13, 380.Google Scholar
- Finn, R. (1961). M.D. Thesis submitted to University of Liverpool.Google Scholar
- Clarke, C. A., Donohoe, W. T. A., McConnell, R. B., and Sheppard, P. M. (1960). Letter submitted to Nature (Lond.).Google Scholar
- Kleihauer, E., and Betke, K. (1960). Der. Internist. 1, 292.Google Scholar
- Levine, P. (1943). J. Hered., 34, 71.Google Scholar
- Race, R. R., and Sanger, R. (1950). Blood Groups in Man, 1st edition. Blackwell, Oxford. (1958). Ibid., 3rd edition. Blackwell, Oxford.Google Scholar
- Stern, K., and Berger, M. (1960). Abstract from American Association of Blood Banks, program, p. 39.Google Scholar
- Davidsohn, I., and Masaitis, L. (1956). Amer. J. clin. Path., 26, 833.Google Scholar