Arsenic pp 232-242 | Cite as

Human carcinogenicity of inorganic arsenic

  • C.-J. Chen
  • Y.-M. Hsueh
  • H.-Y. Chiou
  • Y.-H. Hsu
  • S.-Y. Chen
  • S.-F. Horng
  • K.-F. Liaw
  • M.-M. Wu


Arsenic is widely distributed in nature and mainly transported in the envi ronment by water. All humans are exposed to low levels of arsenic through air, drinking-water, food and beverages. Cigarette smokers may be exposed to arsenic in tobacco, but the chemical form of arsenic in the smoke remains unclear. For most people, food constitutes the largest source of arsenic intake, with smaller amounts from drinking-water and air. Some edible fish, shellfish and seaweed contain elevated levels of arsenic, but this is predomi nately in an organic form that has low toxicity. Above-average levels of arsenic exposure through ingestion have usually been observed among people who live in areas where drinking-water has an elevated level of inorganic arsenic because of natural mineral deposits or contaminations from human activities; among patients treated with drugs containing inorganic arsenic for leukemia, psoriasis and chronic bronchial asthma; and among vintners who consume arsenic-contaminated grape wine. Workers involved in the processing of copper, gold and lead ores; in the use of arsenic as pigments and dyes; in the production and use of agricultural pesticides; in the manufacturing of glass and various pharmaceutical substances; and in the chimney sweeping business also have a high exposure to arsenic (World Health Organization, 1981; US Public Health Service, 1989). Most ingested and inhaled arsenic is well absorbed through the gastro-intestinal tract and lung into the bloodstream. It is distributed in a large number of organs including the lungs, liver, kidneys and skin (Hunter et ai,1942). Most arsenic absorbed in the body is converted by the liver to less toxic methylated forms that are efficiently excreted in the urine (Vahter and Marafante, 1983; Vahter et al,1984).


Bladder Cancer Skin Cancer Sister Chromatid Exchange Arsenic Exposure Inorganic Arsenic 
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  1. Bates, M.N., Smith, A.H. and Hopenhayn-Rich, C. (1992) Arsenic ingestion and internal cancers: A review. Am. J. Epidemiol., 135, 462–76.Google Scholar
  2. Bates, M.N., Smith, A.H. and Cantor, K.P. (1995) Case-control study of bladder cancer and arsenic in drinking water. Am. J. Epidemiol, 141, 525–30.Google Scholar
  3. Brown, C.C. and Chu, K.C. (1983) Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure. J. Natl Cancer Inst., 70, 455–63.Google Scholar
  4. Brown, K.G., Boyle, K.E., Chen, C.W. and Gibb, H.J. (1989) A dose-response analysis of skin cancer from inorganic arsenic in drinking water. Risk Analysis, 9, 519–28.CrossRefGoogle Scholar
  5. Buchet, J.P. and Lauwerys, R. (1987) Study of factors influencing the in vivo methylation of inorganic arsenic in rats. Toxicol, Appl. Pharmacol, 91, 65–74.CrossRefGoogle Scholar
  6. Chen, C.J., Kuo, T.L. and Wu, M.M. (1988) Arsenic and cancers. Lancet, 2, 414–15.CrossRefGoogle Scholar
  7. Chen, C.J. and Wang, C.J. (1990) Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res., 50, 5470–74.Google Scholar
  8. Chen, C.W. and Chen, C.J. (1991) Integrated quantitative cancer risk assessment of inorganic arsenic. Proceeding of the Symposium on Health Risk Assessment on Environmental, Occupational and Lifestyle Hazards (ed. C.P. Wen), pp. 66–80, Institute of Biomedical Sciences, Academia Sinica, Taipei.Google Scholar
  9. Chen, C.J., Chen, C.W., Wu, M.M. and Kuo, T.L. (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer, 66, 888–92.CrossRefGoogle Scholar
  10. Chen, C.J. and Lin, LJ. (1994) Human carcinogenicity and atherogenicity induced by chronic exposure to inorganic arsenic, in Advances in Environmental Science and Technology, Vol. 27, Arsenic in the environment, Part II: Human health and ecosystem effects (ed. J.O. Nriagu), John Wiley, New York, pp. 109–31.Google Scholar
  11. Chiou, H.Y., Hsueh, Y.M., Liaw, K.F. et al. (1995) Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan. Cancer Res., 55, 1296–1300.Google Scholar
  12. Cuzick, J., Sasieni, P. and Evans, S. (1992) Ingested arsenic, keratoses, and bladder cancer. Am. J. Epidemiol., 136, 417–21.Google Scholar
  13. Enterline, P.E. and Marsh, G.M. (1982) Mortality among workers exposed to ar senic and other substances in a copper smelter. Am. J. Epidemiol., 116, 895–910.Google Scholar
  14. Gibb, H. and Chen, C.W. (1989) Is inhaled arsenic carcinogenic for sites other than the lung?, in Assessment of Inhalation Hazards: Integration and Extrapolation Using Diverse Data (eds U. Mohr, D.V. Bates, D.L. Dungworth, P.N. Lee, R.O. McClellan and F.J.C. Roe). Springer-Verlag, Berlin, pp. 169–73.CrossRefGoogle Scholar
  15. Higgins, I., Welch, K. and Burchfiel, C. (1982) Mortality of Anaconda Smelter Workers in Relation to Arsenic and other Exposures, Department of Epidemiol ogy, University of Michigan, Ann Arbor.Google Scholar
  16. Hill, A.B. and Faning, E.L. (1948) Studies on the incidence of cancer in a factory handling inorganic compounds of arsenic. Br. J. Ind. Med., 5, 1–6.Google Scholar
  17. Horng, S.F., Liaw, K.F., Lin, LJ. et al. (1995) A cohort study on lung cancer in the endemic area of blackfoot disease. Chinese J. Public Health (Taipei), 14, 32–40.Google Scholar
  18. Hotta, N. (1989) Clinical aspects of chronic poisoning due to environmental and occupational pollution in and around small refining spot. Jpn. J. Constit. Med., 53, 49–70.Google Scholar
  19. Hsu, Y.H. (1995) Spontaneous and Challenged Sister Chromatid Exchange, Chro mosomal Break and Proliferation Retardation in Peripheral Lymphocytes of Patients Affected with Arsenic-induced Skin Cancer and Matched Healthy Con trols. Institute of Public Health, National Taiwan University, Taipei. Thesis.Google Scholar
  20. Hsueh, Y.M. (1994) Epidemiologie Studies of Skin Cancer in the Endemic Area of Blackfoot Disease in Taiwan. Institute of Public Health, National Taiwan Univer sity, Taipei.Google Scholar
  21. Hsueh, Y.M., Cheng G.S., Wu, M.M. et al. (1995) Multiple risk factors associated with arsenic-induced skin cancer: Effects of chronic liver disease and malnutritional status. Br. J. Cancer, 71, 109–14.CrossRefGoogle Scholar
  22. Hunter, F.T., Kip, A.F. and Irvine, W. (1942) Radioactive tracer studies on arsenic injected as potassium arsenite. J. Pharmacol. Exp. Ther., 76, 207.Google Scholar
  23. International Agency for Research on Cancer (1987) IARC monographs on the Evaluation of Carcinogenic Risks to Humans: Overall Evaluations of Carcinogenicity, an updating of IARC Monographs, Vols 1 to 42. IARC Publ. Suppl., 7, 100–106.Google Scholar
  24. Jacobson-Kram, D. and Montalbano, D. (1985) The Reproductive Effects Assess ment Group’s report on the mutagenicity of inorganic arsenic. Environ. Mutagen., 7, 787–804.CrossRefGoogle Scholar
  25. Jarup, L. and Pershagen, G. (1991) Arsenic exposure, smoking, and lung cancer in smelter workers: A case-control study. Am. J. Epidemiol., 134, 545–51.Google Scholar
  26. Lee-Feldstein, A. (1983) Arsenic and respiratory cancer in man: Follow-up of an occupational study, in Arsenic: Industrial, Biomedical and Environmental Per spectives (eds W. Lederer and M. Fensterheim), Van Nostrand Reinhold, New York.Google Scholar
  27. Luchtrath, H. (1983) The consequences of chronic arsenic poisoning among Moselle wine growers: Pathoanatomical investigations of post-mortem examinations per formed between 1960 and 1977. J. Cancer Res. Clin. Oncol., 105, 173–82.CrossRefGoogle Scholar
  28. Tseng, W.P., Chu, H.M., How, S.W. et al. (1968) Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J. Natl. Cancer Inst., 40, 453–63.Google Scholar
  29. Tsuda, T., Babazono, A., Yamamoto, E. et al. (1995) Ingested arsenic and internal cancer: A historical cohort study followed for 33 years. Am. J. Epidemiol, 141, 198–209.Google Scholar
  30. US Environmental Protection Agency (1988) Risk Assessment Forum. Special Report on Ingested Inorganic Arsenic: Skin Cancer, Nutrition Essentiality. US Environmental Protection Agency, Washington DC.Google Scholar
  31. US Public Health Service (1989) Toxicological Profile for Arsenic. US Public Health Service, Washington DC.Google Scholar
  32. Vahter, M. and Marafante, E. (1983) Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rabbits. Chem. Biol. Interact, 41 29–44.CrossRefGoogle Scholar
  33. Vahter, M., Marafante, E. and Dencker, L. (1984) Tissue distribution and retention of 74AS-dimethyl-arsenic acid in mice and rats. Environ. Contam. Toxicol., 13, 259–64.CrossRefGoogle Scholar
  34. World Health Organization (1981) Environmental Health Criteria, 18, Arsenic, World Health Organization, Geneva.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • C.-J. Chen
  • Y.-M. Hsueh
  • H.-Y. Chiou
  • Y.-H. Hsu
  • S.-Y. Chen
  • S.-F. Horng
  • K.-F. Liaw
  • M.-M. Wu

There are no affiliations available

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