Advertisement

Cell growth and differentiation from the perspective of dynamics and thermodynamics of cellular and subcellular processes

  • M. A. Aon
  • S. Cortassa

Abstract

This chapter develops the concept that spatio—temporal coordination between thousands of chemical reactions inside the cell concerns cellular metabolism and involves enzyme activity modulation by gene expression. It deals with the following questions. Might a balanced pattern of fluxes, genetically and environmentally determined, be a determinant of growth, proliferation or differentiation? Might that pattern of fluxes somehow mediate gene expression and, say, differentiation? In order to illustrate these concepts we will also be dealing specifically with cell commitment to transit through the cell cycle or to sporulation in Saccharomyces cerevisiae and will give experimental and theoretical support for the flux coordination hypothesis as a signal involved in proliferation or differentiation.

Keywords

Metabolic Flux Chemostat Culture Restrictive Temperature Control Coefficient Flux Control Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© M.A. Aon and S. Cortassa 1997

Authors and Affiliations

  • M. A. Aon
    • 1
  • S. Cortassa
    • 1
  1. 1.Research Career Investigator from CONICETArgentina

Personalised recommendations