Skip to main content

The Relationship of 252Cf and226Ra Radiation Doses and the Reoxygenation to Regression of the Cervix Uteri Tumor

Part II: Preliminary results in advanced cervical carcinoma

  • Chapter
Californium-252 Isotope for 21st Century Radiotherapy

Part of the book series: NATO ASI Series ((ASHT,volume 29))

Abstract

Preliminary results of intracavitary treatment with different ratios of 252Cf and 226Ra in IIb stage cervical carcinoma are presented. The group of 75 women was divided into four subgroups: 1) 20 patients treated with conventional radiotherapy, 2) 20 patients treated with 252Cf of 41 Gy-eq in point A supplemented by 40 Gy of 226Ra, 3) 20 patients treated with 41 Gy-eq of 252Cf in point A supplemented by 15 Gy of 226Ra, 4) 15 patient treated with 56 Gy-eq of 252Cf only. The 252Cf sources were administered during the first week of therapy and the 226Ra sources within the period of maximal tumor reoxygenation. A 20 MeV X-ray beam was used for external irradiation to a dose 40 Gy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kallman, R.F.: (1972) The phenomenon of reoxygenation and its implication for fractionated radiotherapy. Radiology, 105, 135–142.

    PubMed  CAS  Google Scholar 

  2. Maruyama, Y., Yoneda, J., Krokikiewicz, H., Mendiondo, O., Beach, J.L., Coffey, C.W., Thompson, D., Wilson, L.C., feola, J., Van Nagel, J.R., Donaldson, E.S. Powell, D.: (1980) A clinical trial for advanced cervico-vaginal pelvic carcinomas using californium-252 fast neutron therapy: report of early responses. Int. J. Radiat. Oncol.Biol.Phys., 6, 1629–1637.

    Article  PubMed  CAS  Google Scholar 

  3. Maruyama, Y., Beach, J.L., Feola, J.: (1980) Schedule od hypoxic-tumor therapy using neutron brachytherapy. Radiology, 137, 775–781.

    PubMed  CAS  Google Scholar 

  4. Maruyama, Y., Van Nagell, J.R., Yoneda, J., Donaldson, E.S., Gellion, H.H., Powell, D., Kryscio, R.J.: (1991) A review of Californium-252 neutron brachytherapy for cervical cancer. Cancer, 68, 1189–1197.

    Article  PubMed  CAS  Google Scholar 

  5. Maruyama, Y., Muir, W.: (1984) Human cerival cancer clearance afer 252Cf nuetron brachytherapy versus conventional photon brachytherapy. Amer.J. Clin. Oncol., 7, 347–352.

    Article  CAS  Google Scholar 

  6. Maruyama, Y., Van Nagell, J.R., Yoneda, J., Donaldson, E.S., Gallion, H.H., Kryscio, R.J.: (1991) Cf-252 neutron brachytherapy treatment for cure of cervical cancer. Nucl.Sci.Appl., 181–192.

    Google Scholar 

  7. Tacev, T., Prokes, B., Strnad, V., Rasovska, O., Krystof, V., Nikodemova, D.: (1989) Effect of small doses 252Cf on the tumour regression in cervix uteri during combined radiotherapy. Strahlenther.Oncol., 165, 837–843.

    CAS  Google Scholar 

  8. Tacev, T., Vacek, A., Strnad, V., Rasovska, O., Krystof, V.: (1991) Radiotherapy of cervix uteri carcinoma with Cf-252 implant nd external hypoxiradiatherapy. Nucl.Sci.Applic, 4, 201–212.

    Google Scholar 

  9. Tacev, T., Vacek, A., Strnad, V., Rasovska, O., Ptackova, B.: (1991) Hypoxiradiotherapy of uterine cervix cancer to decrease of acute side effects and treatment complications. Strahlenther.Oncol., 166,710–713.

    Google Scholar 

  10. Tacev, T., Vacek, A., Prokes, B., Rasovska, O., Krystof, V., Ptackova, B., Strnad, V., Krystof, V.: (1996) On the relationship of 252Cf radiation doses to the reoxygenation and regression of the cervix uteri tumour — Part 1: Clinical experimental study. Radiotherapy and Oncology — in press

    Google Scholar 

  11. Vacek, A., Rotkovska, D., Bartonickova, A., Tacev, T.: (1986) Differences in the radioprotection effects of hypoxic hypoxie in normal tissue and in experimental tumours. Int. J. Radiat. Oncol. Biol., 49, 858.

    Google Scholar 

  12. Yaes, R.J.: (1989) Tumour Heterogenity, tumor size and radioresistance. Int. J. Radiat. Oncol. Biol. Phys., 17, 993–1005.

    Article  PubMed  CAS  Google Scholar 

  13. Yaes, R.J., Berner, B., Yoneda, J., Feola, J.M., Maruyama, Y.: (1991) Explanation for the efficacy of early versus delayed Californium Brachytherapy for bulky cervix cancer, Nucl.Sci.Applic., 4, 107–115.

    Google Scholar 

  14. Yarmonenko, S.P., Vainson, A.A., Bereznova, L.I., Klimker, V.M., Ovakimov, V.G., Petrosian, E.P., Shmakova, N.I.: (1976) The selective protection of normal tissues by irradiation of tumor-bearing mice in hypoxic hypoxia. Radiat.Res., 67, 447–458.

    Article  PubMed  CAS  Google Scholar 

  15. Yarmonenko, S.P.: (1988) Radiobiology of humans and animals. Mir Publisher, Moscow.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Tačev, T. et al. (1997). The Relationship of 252Cf and226Ra Radiation Doses and the Reoxygenation to Regression of the Cervix Uteri Tumor. In: Wierzbicki, J.G. (eds) Californium-252 Isotope for 21st Century Radiotherapy. NATO ASI Series, vol 29. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5766-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5766-7_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6433-0

  • Online ISBN: 978-94-011-5766-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics