Abstract
In a patient with acute myocardial infarction, clinical, electrocardiographic and angiographic information may be inadequate for determining the presence of viable tissue. If wall thickening is present, the myocardium is viable; if wall thickening is absent, the myocardium may or may not be viable [1]. The basis for the underlying myocardial dysfunction may be multifactorial in a single patient or even in a single myocardial segment. Myocardial contrast echocardiography (MCE) can define regions of viability within the infarct zone based on its ability to demonstrate the spatial distribution of microvascular perfusion [2]. The magnitude and spatial extent of microvascular perfusion within the infarct zone is the predominant determinant of the extent of myocellular viability.
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References
Lieberman AN, Weiss JL, Jugdutt BI et al. Two-dimensional echocardiography and infarct size: Relationship of regional wall motion and thinning to the extent of myocardial infarction in the dog. Circulation 1981;63:739–46.
Kaul S, Force T. Assessment of myocardial perfusion with contrast two-dimensional echocardiography. In: Principles and Practice of Echocardiography. 2nd edn. Weyman AE, editor. Philadelphia: Lea and Febiger, 1993;687–720.
Oxford English Dictionary. Oxford: Oxford University Press, 1971.
Gropler RJ, Bergmann SR. Myocardial viability-what is the definition? J Nucl Med 1991;32:10–2.
Myers JH, Stirling MC, Choy M, Buda AJ, Gallagher KP. Direct measurement of inner and outer wall thickening dynamics with epicardial echocardiography. Circulation 1986;74:164–72.
Weintraub WS, Hattori S, Aggarwal JB, Bodenheimer MM, Banka V, Halfant RH. The relationship between myocardial blood flow and contraction by myocardial layer in the canine left ventricle during ischemia. Circ Res 1981;48:430–8.
Touchstone DA, Beller GA, Nygaard TW, Tedesco C, Kaul S. Effects of successful intravenous reperfusion therapy on regional myocardial function and geometry in man: A tomographic assessment using two-dimensional echocardiography. J Am Coll Cardiol 1989;13:1506–13.
Penco M, Romano S, Agati L et al. Influence of reperfusion induced by thrombolytic treatment on natural history of left ventricular regional motion abnormality in acute myocardial infarction. Am J Cardiol 1993;71:1015–20.
Widemsky, Cervenka V, Visek V, Sladkova T, Dvorak J, Drdlicka S. First month course of left ventricular asynergy after intracoronary thrombolysis in acute myocardial infarction: A longitudinal echocardiographic study. Eur Heart J 1985;6:759–65.
Charuzi Y, Beeder C, Marshall LA et al. Improvement in regional and global left ventricular function after intracoronary thrombolysis: assessment with two-dimensional echocardiography. Am J Cardiol 1984;53:662–5.
Sklenar J, Villanueva FS, Glasheen WP, Ismail S, Goodman NC, Kaul S. Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion: an experimental evaluation. Circulation 1994;90:1503–12.
Marino P, Zanolla L, Zardini P. Effect of streptokinase on left ventricular modeling and function after myocardial infarction: The GISSI (Gruppo Italiano per Studio della Streptochinasi nell’Infarto Miocardico) Trial. JAm Coll Cardiol 1989;14:1149–58.
Reimer KA, Jennings RB. The ‘wavefront phenomenon’ of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 1979;40:633–44.
Jugdutt BI, Hutchins GM, Bulkley BM, Becker LC. Myocardial infarction in the conscious dog: Three-dimensional mapping of infarct, collateral flow and region at risk. Circulation 1979;60:1141–50.
Kloner RA, Ganote CE, Jennings RB. The ‘no-reflow phenomenon’ after temporary coronary occlusion in the dog. J Clin Invest 1974;54:1496–508.
White FC, Sanders M, Bloor CM. Regional redistribution of myocardial blood flow after coronary occlusion and reperfusion in the conscious dog. Am J Cardiol 1978;42:234–43.
West PN, Connors JP, Clark RE, Weldon CS. Compromised microvascular integrity in ischemic myocardium. Lab Invest 1978;38:677–84.
Kaul S, Kelly P, Oliner JD, Glasheen WP, Keller MW, Watson DD. Assessment of regional myocardial blood flow with myocardial contrast two-dimensional echocardiography. J Am Coll Cardiol 1989;13:468–82.
Sabia PJ, Powers ER, Jayaweera AR, Ragosta M, Kaul S. Functional significance of collateral blood flow in patients with recent acute myocardial infarction. A study using myocardial contrast echocardiography. Circulation 1992;85:2080–9.
Gensini GG, daCosta BCB. The coronary collateral circulation in living man. Am J Cardiol 1969;24:393–400.
Cohen MV. Morphological considerations of the coronary collateral circulation in man. In:Coronary Collaterals. New York: Futura Publishing Co. 1985:1–91.
Sabia PJ, Powers ER, Ragosta M, Sarembock IJ, Burwell L, Kaul S. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med 1992;327:1825–31.
Ito H, Tomooka T, Sakai N, Yu H et al. Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation 1992;85:1699–705.
Ragosta M, Camarano GP, Kaul S, Powers E, Gimple LW. Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction: new insights using myocardial contrast echocardiography. Circulation 1994;89:2562–9.
Lim Y-J, Nanto S, Masuyama T et al. Myocardial salvage: Its assessment and prediction by the analysis of serial myocardial contrast echocardiograms in patients with acute myocardial infarction. Am Heart J 1994;128:649–56.
Agati L, Voci P, Bilotta F et al. Influence of residual perfusion within the infarct zone on the natural history of left ventricular dysfunction after acute myocardial infarction: a myocardial contrast echocardiographic study. J Am Coll Cardiol 1994;24:336–42.
Camarano G, Ragosta M, Gimple LW, Powers ER, Kaul S. Identification of viable myocardium with contrast echocardiography in patients with poor left ventricular systolic function caused by recent or remote myocardial infarction. Am J Cardiol 1995;75:215–9.
Villanueva FS, Glasheen WD, Sklenar J, Kaul S. Assessment of risk area during coronary occlusion and infarct size after reperfusion with myocardial contrast echocardiography using left and right atrial injections of contrast. Circulation 1993;88:596–604.
Johnson WB, Malone SA, Pantely G et al. No reflow and extent of infarction during maximal vasodilatation in the porcine heart. Circulation 1988;78:462–72.
Vanhaecke J, Flameng W, Borgers M et al. Evidence for decreased coronary flow reserve in viable postischemic myocardium. Circ Res 1990;67:1201–10.
Villanueva FS, Glasheen WP, Sklenar J, Kaul S. Characterization of spatial patterns of flow within the reperfused myocardium using myocardial contrast echocardiography: Implications for determining extent of myocardial salvage. Circulation 1993;88:2596–606.
Skyba DM, Camarano G, Goodman NC, Price RJ, Skalak TC, Kaul S. Hemodynamic characteristics, myocardial kinetics, and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection. J Am Coll Cardiol 1996;28:1292–300.
Porter TR, Xie F. Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles. Demonstration of potential mechanisms. Circulation 1995;92:2391–5.
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Firschke, C., Kaul, S. (1997). Assessment of myocardial viability post-infarction with myocardial contrast echocardiography. In: Nanda, N.C., Schlief, R., Goldberg, B.B. (eds) Advances in Echo Imaging Using Contrast Enhancement. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5704-9_25
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DOI: https://doi.org/10.1007/978-94-011-5704-9_25
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