Abstract
Fluoroquinolones such as pefloxacin are antimicrobial agents with an excellent activity against various bacteria. The activity of fluoroquinolones depends on two factors: their uptake by the cell and their specific inhibition of the activity of DNA gyrase, an enzyme involved in the supercoiling of DNA. Some cations such as Mg2+ and Ca2+ cause maladsorption of most fluoroquinolones, what may result in therapeutic failure. Furthermore, conflicting reports have been accumulated in the literature on the mechanism of action of the quinolone, which implicates also magnesium.1-3
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© 1997 Springer Science+Business Media Dordrecht
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Lecomte, S., Chenon, M.T., Baron, M.H. (1997). Mechanism of Activity of Fluoroquinolones. In: Carmona, P., Navarro, R., Hernanz, A. (eds) Spectroscopy of Biological Molecules: Modern Trends. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5622-6_185
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DOI: https://doi.org/10.1007/978-94-011-5622-6_185
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